DegronMD - P35052(GPC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R210C	TCGA-21-5786	LUSC	TCGA	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.R210C	TCGA-EO-A22U	UCEC	TCGA	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.R210C	DO233207	GACA	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.R210C	DO26830	LUSC	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.R210C	DO43755	UCEC	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.R210C	SIDM01120	Other Solid Cancers	GDSC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.R210C	SIDM00136	Colorectal Carcinoma	GDSC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.R210C	NCI-H720	lung	COSMIC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1667
p.G203R	TCGA-AZ-6605	COAD	TCGA	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.6457
p.G203R	DO8762	COAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.6457
p.G203R	DO229005	COCA	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.6457
p.G203R	DO234377	ESAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.6457
p.A198V	TCGA-CG-4305	STAD	TCGA	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.3056
p.A198V	DO38823	STAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.3056
p.A198V	SIDM00791	Chronic Myelogenous Leukemia	GDSC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.3056
p.A198V	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.3056
p.R212W	TCGA-KK-A59V	PRAD	TCGA	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1111
p.R212W	DO51346	PRAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.1111
p.R200W	DO227844	COCA	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.7523
p.T214A	DO227987	COCA	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.0556
p.P206L	DO220947	WT	ICGC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.2778
p.E204D	SIDM01245	T-Lymphoblastic Leukemia	GDSC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.5647
p.E204D	ACH-002216	Leukemia	CCLE	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.5647
p.E204D	BE-13	haematopoietic and lymphoid tissue	COSMIC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation altering degron motif	0.5647
p.R207K	SIDM01178	Other Solid Cancers	GDSC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.25
p.R207K	ACH-002200	Skin Cancer	CCLE	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.25
p.R207K	SW962	vulva	COSMIC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.25
p.A213V	SIDM00217	Colorectal Carcinoma	GDSC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.0833
p.A213V	ACH-000999	Colon/Colorectal Cancer	CCLE	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.0833
p.A213V	SNU-1040	large intestine	COSMIC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.0833
p.D213N	Hs633T	soft tissue	COSMIC	LRPFGE	LIG_APCC_ABBA_1	199:204	Mutation rewiring degron network	0.0833

Kaplan plot for GPC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPC1

UniProt ID: P35052

Entrez ID: 2817

Protein name: Glypican-1 [Cleaved into: Secreted glypican-1]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPC1 in