DegronMD

Uniprot ID: P35052

Source protein: Glypican-1 [Cleaved into: Secreted glypican-1]

Source gene: GPC1

Class: LIG_APCC_ABBA_1

Location: 199:204

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5685

ASA_SCORE: 70.7667

COIL: 0.7592

CONS_SCORE: 0.7102

DSS_SCORE: 0.2598

HELIX: 0.2112

FCONS_SCORE: 1.2825

RIG_SCORE: 0.763

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R210C	TCGA-21-5786	LUSC	TCGA	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.R210C	TCGA-EO-A22U	UCEC	TCGA	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.R210C	DO233207	GACA	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.R210C	DO26830	LUSC	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.R210C	DO43755	UCEC	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.R210C	SIDM01120	Other Solid Cancers	GDSC	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.R210C	SIDM00136	Colorectal Carcinoma	GDSC	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.R210C	NCI-H720	lung	COSMIC	LRPFGE	LIG_APCC_ABBA_1	0.1667
p.G203R	TCGA-AZ-6605	COAD	TCGA	LRPFGE	LIG_APCC_ABBA_1	0.6457
p.G203R	DO8762	COAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.6457
p.G203R	DO229005	COCA	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.6457
p.G203R	DO234377	ESAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.6457
p.A198V	TCGA-CG-4305	STAD	TCGA	LRPFGE	LIG_APCC_ABBA_1	0.3056
p.A198V	DO38823	STAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.3056
p.A198V	SIDM00791	Chronic Myelogenous Leukemia	GDSC	LRPFGE	LIG_APCC_ABBA_1	0.3056
p.A198V	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	LRPFGE	LIG_APCC_ABBA_1	0.3056
p.R212W	TCGA-KK-A59V	PRAD	TCGA	LRPFGE	LIG_APCC_ABBA_1	0.1111
p.R212W	DO51346	PRAD	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.1111
p.R200W	DO227844	COCA	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.7523
p.T214A	DO227987	COCA	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.0556
p.P206L	DO220947	WT	ICGC	LRPFGE	LIG_APCC_ABBA_1	0.2778
p.E204D	SIDM01245	T-Lymphoblastic Leukemia	GDSC	LRPFGE	LIG_APCC_ABBA_1	0.5647
p.E204D	ACH-002216	Leukemia	CCLE	LRPFGE	LIG_APCC_ABBA_1	0.5647
p.E204D	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	LRPFGE	LIG_APCC_ABBA_1	0.5647
p.R207K	SIDM01178	Other Solid Cancers	GDSC	LRPFGE	LIG_APCC_ABBA_1	0.25
p.R207K	ACH-002200	Skin Cancer	CCLE	LRPFGE	LIG_APCC_ABBA_1	0.25
p.R207K	SW962	vulva	COSMIC	LRPFGE	LIG_APCC_ABBA_1	0.25
p.A213V	SIDM00217	Colorectal Carcinoma	GDSC	LRPFGE	LIG_APCC_ABBA_1	0.0833
p.A213V	ACH-000999	Colon/Colorectal Cancer	CCLE	LRPFGE	LIG_APCC_ABBA_1	0.0833
p.A213V	SNU-1040	large_intestine	COSMIC	LRPFGE	LIG_APCC_ABBA_1	0.0833
p.D213N	Hs633T	soft_tissue	COSMIC	LRPFGE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRPFGE

Degron related mutations and impact score

Drug responses associated with GPC1 mutations

All proteins holding degron of LRPFGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35052	Glypican-1 [Cleaved into: Secreted glypican-1]	LIG_APCC_ABBA_1	199:204	LRPFGE	APC,CDC20,FZR1	0.5685	More...