DegronMD - P35212(GJA4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R304S	TCGA-13-0894	OV	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation altering degron motif	0.7427
p.R304S	DO28591	OV	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation altering degron motif	0.7427
p.P305S	TCGA-13-0894	OV	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation altering degron motif	0.5641
p.P305S	DO28591	OV	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation altering degron motif	0.5641
p.R299T	TCGA-2Z-A9J2	KIRP	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.1944
p.R299T	DO219650	KIRP	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.1944
p.P311S	TCGA-BR-4361	STAD	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.3056
p.P311S	DO38887	STAD	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.3056
p.P313T	TCGA-CV-6943	HNSC	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.25
p.P313T	DO15511	HNSC	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.25
p.S303F	TCGA-IB-7651	PAAD	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.3056
p.S303F	DO46657	PAAD	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.3056
p.P319S	DO229016	COCA	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation blocking phosphorylation signal	0.5278
p.P319S	DO229005	COCA	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation blocking phosphorylation signal	0.5278
p.T296I	SIDM00120	Prostate Carcinoma	GDSC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.1111
p.T296I	ACH-000979	Prostate Cancer	CCLE	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.1111
p.T296I	DU-145	prostate	COSMIC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.1111
p.P320S	SIDM00814	Other Solid Cancers	GDSC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.0556
p.P320S	ACH-001401	Adrenal Cancer	CCLE	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.0556
p.P320S	SW13	adrenal gland	COSMIC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	304:310	Mutation rewiring degron network	0.0556

Kaplan plot for GJA4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GJA4

UniProt ID: P35212

Entrez ID: 2701

Protein name: Gap junction alpha-4 protein (Connexin-37) (Cx37)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for GJA4 in