DegronMD

Uniprot ID: P35212

Source protein: Gap junction alpha-4 protein

Source gene: GJA4

Class: LIG_APCC_ABBAyCdc20_2

Location: 304:310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9753

ASA_SCORE: 101.1

COIL: 0.9487

CONS_SCORE: 0.2585

DSS_SCORE: 0.7861

HELIX: 0.035

FCONS_SCORE: 0.7222

RIG_SCORE: 0.6471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R304S	TCGA-13-0894	OV	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.7427
p.R304S	DO28591	OV	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.7427
p.P305S	TCGA-13-0894	OV	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.5641
p.P305S	DO28591	OV	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.5641
p.R299T	TCGA-2Z-A9J2	KIRP	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R299T	DO219650	KIRP	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P311S	TCGA-BR-4361	STAD	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P311S	DO38887	STAD	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P313T	TCGA-CV-6943	HNSC	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.25
p.P313T	DO15511	HNSC	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.25
p.S303F	TCGA-IB-7651	PAAD	TCGA	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S303F	DO46657	PAAD	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P319S	DO229016	COCA	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.5278
p.P319S	DO229005	COCA	ICGC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.5278
p.T296I	SIDM00120	Prostate Carcinoma	GDSC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T296I	ACH-000979	Prostate Cancer	CCLE	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T296I	DU-145	prostate	COSMIC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P320S	SIDM00814	Other Solid Cancers	GDSC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P320S	ACH-001401	Adrenal Cancer	CCLE	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P320S	SW13	adrenal_gland	COSMIC	RPPLFLD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35212	Gap junction alpha-4 protein	LIG_APCC_ABBAyCdc20_2	304:310	RPPLFLD	APC,CDC20,FZR1	0.9753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons