DegronMD - P35222(CTNNB1)

FUNCTION: Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that pr... FUNCTION: Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938}. View more >>

GO - Biological processes (BP): adherens junction assembly [GO:0034333]; anterior/posterior axis specification [GO:0009948]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in ureteric bud morphogenesis [GO:0001658... adherens junction assembly [GO:0034333]; anterior/posterior axis specification [GO:0009948]; astrocyte-dopaminergic neuron signaling [GO:0036520]; bone resorption [GO:0045453]; branching involved in blood vessel morphogenesis [GO:0001569]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [GO:0044334]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell fate specification [GO:0001708]; cell-matrix adhesion [GO:0007160]; cell maturation [GO:0048469]; cell morphogenesis involved in differentiation [GO:0000904]; cellular response to growth factor stimulus [GO:0071363]; cellular response to indole-3-methanol [GO:0071681]; central nervous system vasculogenesis [GO:0022009]; chemical synaptic transmission [GO:0007268]; cranial ganglion development [GO:0061550]; cranial skeletal system development [GO:1904888]; detection of muscle stretch [GO:0035995]; dorsal/ventral axis specification [GO:0009950]; dorsal root ganglion development [GO:1990791]; ectoderm development [GO:0007398]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic foregut morphogenesis [GO:0048617]; embryonic forelimb morphogenesis [GO:0035115]; embryonic heart tube development [GO:0035050]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal limb joint morphogenesis [GO:0036023]; endodermal cell fate commitment [GO:0001711]; endothelial tube morphogenesis [GO:0061154]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial to mesenchymal transition [GO:0001837]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; fungiform papilla formation [GO:0061198]; gastrulation with mouth forming second [GO:0001702]; genitalia morphogenesis [GO:0035112]; glial cell fate determination [GO:0007403]; hair cell differentiation [GO:0035315]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; hindbrain development [GO:0030902]; in utero embryonic development [GO:0001701]; layer formation in cerebral cortex [GO:0021819]; lens morphogenesis in camera-type eye [GO:0002089]; lung-associated mesenchyme development [GO:0060484]; lung cell differentiation [GO:0060479]; lung induction [GO:0060492]; male genitalia development [GO:0030539]; mesenchymal cell proliferation involved in lung development [GO:0060916]; mesenchymal stem cell differentiation [GO:0072497]; metanephros morphogenesis [GO:0003338]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of gene expression [GO:0010629]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of mitotic cell cycle, embryonic [GO:0045976]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephron tubule formation [GO:0072079]; neural plate development [GO:0001840]; neuron migration [GO:0001764]; neuron projection extension [GO:1990138]; odontogenesis of dentin-containing tooth [GO:0042475]; oocyte development [GO:0048599]; osteoclast differentiation [GO:0030316]; oviduct development [GO:0060066]; pancreas development [GO:0031016]; positive regulation of apoptotic process [GO:0043065]; positive regulation of branching involved in lung morphogenesis [GO:0061047]; positive regulation of cell differentiation [GO:0045597]; positive regulation of core promoter binding [GO:1904798]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of gene expression [GO:0010628]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein localization to cell surface [GO:0034394]; protein polyubiquitination [GO:0000209]; proximal/distal pattern formation [GO:0009954]; regulation of angiogenesis [GO:0045765]; regulation of calcium ion import [GO:0090279]; regulation of centriole-centriole cohesion [GO:0030997]; regulation of centromeric sister chromatid cohesion [GO:0070602]; regulation of fibroblast proliferation [GO:0048145]; regulation of myelination [GO:0031641]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neurogenesis [GO:0050767]; regulation of protein localization to cell surface [GO:2000008]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of T cell proliferation [GO:0042129]; regulation of timing of anagen [GO:0051884]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; renal vesicle formation [GO:0072033]; response to estradiol [GO:0032355]; response to xenobiotic stimulus [GO:0009410]; smooth muscle cell differentiation [GO:0051145]; stem cell population maintenance [GO:0019827]; sympathetic ganglion development [GO:0061549]; synapse organization [GO:0050808]; synaptic vesicle clustering [GO:0097091]; synaptic vesicle transport [GO:0048489]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; trachea formation [GO:0060440] View more >>

GO - Molecular function (MF): alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; disordered domain specific binding [GO:0097718]; DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; estrogen receptor binding [GO:003... View more >>

GO - Cellular component (CC): adherens junction [GO:0005912]; apical part of cell [GO:0045177]; apicolateral plasma membrane [GO:0016327]; basolateral plasma membrane [GO:0016323]; beta-catenin destruction complex [GO:0030877]; beta-catenin-ICAT complex [GO:1990711]; beta-catenin-TCF7L2 complex [GO:0070369]; beta-catenin-TCF com... View more >>

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DSGIHS	DEG_SCF_TRCP1_1	BTRC	Catenin beta-1	32:37	More..
RAAMFPE	LIG_APCC_ABBAyCdc20_2	APC,CDC20,FZR1	Catenin beta-1	95:101	More..

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S37F	TCGA-05-4422	LUAD	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-17-Z032	LUAD	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-4E-A92E	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-55-8085	LUAD	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-5C-A9VG	LIHC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-78-7158	LUAD	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-86-8280	LUAD	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-A5-A0GM	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-AJ-A3BK	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-AX-A0J0	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-AX-A3FZ	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-BG-A0MG	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-BG-A0VT	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-BL-A5ZZ	BLCA	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-BW-A5NQ	LIHC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-D1-A0ZQ	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-D1-A16B	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-D1-A16Q	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-D1-A17R	UCEC	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093
p.S37F	TCGA-D7-6822	STAD	TCGA	DSGIHS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.9093

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTNNB1

UniProt ID: P35222

Entrez ID: 1499

Protein name: Catenin beta-1 (Beta-catenin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CTNNB1 in