DegronMD

Uniprot ID: P35222

Source protein: Catenin beta-1

Source gene: CTNNB1

Class: LIG_APCC_ABBAyCdc20_2

Location: 95:101

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9802

ASA_SCORE: 82.6857

COIL: 0.4344

CONS_SCORE: 0.3891

DSS_SCORE: 0.4258

HELIX: 0.5529

FCONS_SCORE: 1.2521

RIG_SCORE: 0.7808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R90Q	TCGA-AA-3510	COAD	TCGA	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V94E	TCGA-AP-A1DP	UCEC	TCGA	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E101D	TCGA-AP-A1DV	UCEC	TCGA	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.5647
p.P100H	TCGA-D3-A2JC	SKCM	TCGA	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.6583
p.R93S	TCGA-EE-A20F	SKCM	TCGA	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M98V	TCGA-EW-A6SD	BRCA	TCGA	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.6097
p.R90L	TCGA-LN-A7HX	ESCA	TCGA	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.M91V	DO223936	BRCA	ICGC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R86S	DO37961	SKCM	ICGC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.5278
p.P93H	DO47578	SKCM	ICGC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V87E	DO42336	UCEC	ICGC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E94D	DO43186	UCEC	ICGC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D108Y	SCH	stomach	COSMIC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A98V	SNU-1040	large_intestine	COSMIC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.6936
p.R107H	SNU-1040	large_intestine	COSMIC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A91V	SNU-1040	large_intestine	COSMIC	RAAMFPE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35222	Catenin beta-1	LIG_APCC_ABBAyCdc20_2	95:101	RAAMFPE	APC,CDC20,FZR1	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons