DegronMD - P35228(NOS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K66M	TCGA-AA-A010	COAD	TCGA	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation substituting flanking lysine	0.2222
p.S67F	TCGA-D9-A6EC	SKCM	TCGA	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.1389
p.S67F	DO50291	SKCM	ICGC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.1389
p.V72G	TCGA-EO-A3B0	UCEC	TCGA	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.2778
p.V72G	DO219773	UCEC	ICGC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.2778
p.G91S	TCGA-FW-A3R5	SKCM	TCGA	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.0556
p.G91S	DO37406	SKCM	ICGC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.0556
p.P82L	TCGA-FW-A3R5	SKCM	TCGA	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.3056
p.P82L	DO37406	SKCM	ICGC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.3056
p.P78S	TCGA-IB-7651	PAAD	TCGA	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation altering degron motif	0.6752
p.P78S	DO46657	PAAD	ICGC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation altering degron motif	0.6752
p.W90R	DO50341	ESAD	ICGC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation rewiring degron network	0.0833
p.S81Y	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation altering degron motif	0.712
p.S81Y	ACH-000121	Lung Cancer	CCLE	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation altering degron motif	0.712
p.S81Y	NCI-H2405	lung	COSMIC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation altering degron motif	0.712
p.S80Y	NCI-H2405	lung	COSMIC	LDATPLSS	DEG_SCF_FBW7_1	74:81	Mutation altering degron motif	0.6009

Kaplan plot for NOS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOS2

UniProt ID: P35228

Entrez ID: 4843

Protein name: Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOS2 in