DegronMD

Uniprot ID: P35228

Source protein: Nitric oxide synthase, inducible

Source gene: NOS2

Class: DEG_SCF_FBW7_1

Location: 74:81

E3 ligase: FBXW7

DEGRON score: 0.9754

ASA_SCORE: 84.3

COIL: 0.9289

CONS_SCORE: 0.2803

DSS_SCORE: 0.5157

HELIX: 0.0417

FCONS_SCORE: 0.9242

RIG_SCORE: 0.6979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K66M	TCGA-AA-A010	COAD	TCGA	LDATPLSS	DEG_SCF_FBW7_1	0.2222
p.S67F	TCGA-D9-A6EC	SKCM	TCGA	LDATPLSS	DEG_SCF_FBW7_1	0.1389
p.S67F	DO50291	SKCM	ICGC	LDATPLSS	DEG_SCF_FBW7_1	0.1389
p.V72G	TCGA-EO-A3B0	UCEC	TCGA	LDATPLSS	DEG_SCF_FBW7_1	0.2778
p.V72G	DO219773	UCEC	ICGC	LDATPLSS	DEG_SCF_FBW7_1	0.2778
p.G91S	TCGA-FW-A3R5	SKCM	TCGA	LDATPLSS	DEG_SCF_FBW7_1	0.0556
p.G91S	DO37406	SKCM	ICGC	LDATPLSS	DEG_SCF_FBW7_1	0.0556
p.P82L	TCGA-FW-A3R5	SKCM	TCGA	LDATPLSS	DEG_SCF_FBW7_1	0.3056
p.P82L	DO37406	SKCM	ICGC	LDATPLSS	DEG_SCF_FBW7_1	0.3056
p.P78S	TCGA-IB-7651	PAAD	TCGA	LDATPLSS	DEG_SCF_FBW7_1	0.6752
p.P78S	DO46657	PAAD	ICGC	LDATPLSS	DEG_SCF_FBW7_1	0.6752
p.W90R	DO50341	ESAD	ICGC	LDATPLSS	DEG_SCF_FBW7_1	0.0833
p.S81Y	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	LDATPLSS	DEG_SCF_FBW7_1	0.712
p.S81Y	ACH-000121	Lung Cancer	CCLE	LDATPLSS	DEG_SCF_FBW7_1	0.712
p.S81Y	NCI-H2405	lung	COSMIC	LDATPLSS	DEG_SCF_FBW7_1	0.712
p.S80Y	NCI-H2405	lung	COSMIC	LDATPLSS	DEG_SCF_FBW7_1	0.6009

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35228	Nitric oxide synthase, inducible	DEG_SCF_FBW7_1	74:81	LDATPLSS	FBXW7	0.9754	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons