DegronMD - P35443(THBS4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G137V	TCGA-18-3414	LUSC	TCGA	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2222
p.S132R	TCGA-BS-A0UF	UCEC	TCGA	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0833
p.D151H	TCGA-C8-A8HQ	BRCA	TCGA	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.S140F	TCGA-CJ-5686	KIRC	TCGA	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.R136Q	TCGA-D3-A8GI	SKCM	TCGA	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.R136Q	SIDM00631	Breast Carcinoma	GDSC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.R136Q	MDA-MB-330	breast	COSMIC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.E142K	TCGA-FW-A3R5	SKCM	TCGA	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.591
p.Q149R	TCGA-O8-A75V	LIHC	TCGA	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.25
p.D148G	DO229056	LICA	ICGC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2778
p.L149F	DO229494	SKCA	ICGC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.25
p.F132L	DO41020	UCEC	ICGC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0833
p.V154I	DO52412	UCEC	ICGC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1111
p.V153I	SIDM01144	Gastric Carcinoma	GDSC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1389
p.V153I	NCI-SNU-5	stomach	COSMIC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1389
p.C147F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.C147F	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LELYLD	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056

Kaplan plot for THBS4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THBS4

UniProt ID: P35443

Entrez ID: 7060

Protein name: Thrombospondin-4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THBS4 in