DegronMD

Uniprot ID: P35443

Source protein: Thrombospondin-4

Source gene: THBS4

Class: LIG_APCC_ABBA_1

Location: 141:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5997

ASA_SCORE: 26.9

COIL: 0.1715

CONS_SCORE: 0.4479

DSS_SCORE: 0.0846

HELIX: 0.0123

FCONS_SCORE: 1.3124

RIG_SCORE: 0.8491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G137V	TCGA-18-3414	LUSC	TCGA	LELYLD	LIG_APCC_ABBA_1	0.2222
p.S132R	TCGA-BS-A0UF	UCEC	TCGA	LELYLD	LIG_APCC_ABBA_1	0.0833
p.D151H	TCGA-C8-A8HQ	BRCA	TCGA	LELYLD	LIG_APCC_ABBA_1	0.1944
p.S140F	TCGA-CJ-5686	KIRC	TCGA	LELYLD	LIG_APCC_ABBA_1	0.3056
p.R136Q	TCGA-D3-A8GI	SKCM	TCGA	LELYLD	LIG_APCC_ABBA_1	0.1944
p.R136Q	SIDM00631	Breast Carcinoma	GDSC	LELYLD	LIG_APCC_ABBA_1	0.1944
p.R136Q	MDA-MB-330	breast	COSMIC	LELYLD	LIG_APCC_ABBA_1	0.1944
p.E142K	TCGA-FW-A3R5	SKCM	TCGA	LELYLD	LIG_APCC_ABBA_1	0.591
p.Q149R	TCGA-O8-A75V	LIHC	TCGA	LELYLD	LIG_APCC_ABBA_1	0.25
p.D148G	DO229056	LICA	ICGC	LELYLD	LIG_APCC_ABBA_1	0.2778
p.L149F	DO229494	SKCA	ICGC	LELYLD	LIG_APCC_ABBA_1	0.25
p.F132L	DO41020	UCEC	ICGC	LELYLD	LIG_APCC_ABBA_1	0.0833
p.V154I	DO52412	UCEC	ICGC	LELYLD	LIG_APCC_ABBA_1	0.1111
p.V153I	SIDM01144	Gastric Carcinoma	GDSC	LELYLD	LIG_APCC_ABBA_1	0.1389
p.V153I	NCI-SNU-5	stomach	COSMIC	LELYLD	LIG_APCC_ABBA_1	0.1389
p.C147F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LELYLD	LIG_APCC_ABBA_1	0.3056
p.C147F	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LELYLD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35443	Thrombospondin-4	LIG_APCC_ABBA_1	141:146	LELYLD	APC,CDC20,FZR1	0.5997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons