DegronMD - P35557(GCK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E52Q	TCGA-17-Z031	LUAD	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0556
p.G69S	TCGA-B5-A3FC	UCEC	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.6993
p.R64H	TCGA-D3-A2JF	SKCM	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.8244
p.S65F	TCGA-D6-A74Q	HNSC	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7982
p.T66I	TCGA-DA-A3F3	SKCM	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7078
p.P67S	TCGA-EE-A29G	SKCM	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.6752
p.R63H	DO233823	GACA	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.R63H	DO38153	SKCM	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7133
p.S64F	DO52087	HNSC	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.6871
p.S64F	DO231957	LICA	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.6871
p.L75F	DO222908	MELA	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1667
p.T65I	DO37607	SKCM	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7078
p.P66S	DO47303	SKCM	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.6752
p.G68S	DO41871	UCEC	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.5882
p.S77F	SIDM01060	Melanoma	GDSC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1111
p.S77F	IGR-1	skin	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1111
p.R64C	SIDM00534	Colorectal Carcinoma	GDSC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.8301
p.R64C	HT-115	large intestine	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.8301
p.S76F	ACH-000882	Skin Cancer	CCLE	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.S76F	IGR-1	skin	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.R63C	ACH-000986	Colon/Colorectal Cancer	CCLE	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.719
p.R63C	HT-115	large intestine	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.719
p.R62C	HT-115	large intestine	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.8301
p.S75F	IGR-1	skin	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1667

Kaplan plot for GCK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GCK

UniProt ID: P35557

Entrez ID: 2645

Protein name: Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GCK in