DegronMD

Uniprot ID: P35557

Source protein: Hexokinase-4

Source gene: GCK

Class: DEG_SCF_FBW7_1

Location: 62:69

E3 ligase: FBXW7

DEGRON score: 0.8507

ASA_SCORE: 60.425

COIL: 0.6673

CONS_SCORE: 0.5598

DSS_SCORE: 0.4176

HELIX: 0.0301

FCONS_SCORE: 0.8591

RIG_SCORE: 0.7082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E52Q	TCGA-17-Z031	LUAD	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	0.0556
p.G69S	TCGA-B5-A3FC	UCEC	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	0.6993
p.R64H	TCGA-D3-A2JF	SKCM	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	0.8244
p.S65F	TCGA-D6-A74Q	HNSC	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	0.7982
p.T66I	TCGA-DA-A3F3	SKCM	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	0.7078
p.P67S	TCGA-EE-A29G	SKCM	TCGA	VRSTPEGS	DEG_SCF_FBW7_1	0.6752
p.R63H	DO233823	GACA	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.7133
p.R63H	DO38153	SKCM	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.7133
p.S64F	DO52087	HNSC	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.6871
p.S64F	DO231957	LICA	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.6871
p.L75F	DO222908	MELA	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.1667
p.T65I	DO37607	SKCM	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.7078
p.P66S	DO47303	SKCM	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.6752
p.G68S	DO41871	UCEC	ICGC	VRSTPEGS	DEG_SCF_FBW7_1	0.5882
p.S77F	SIDM01060	Melanoma	GDSC	VRSTPEGS	DEG_SCF_FBW7_1	0.1111
p.S77F	IGR-1	skin	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	0.1111
p.R64C	SIDM00534	Colorectal Carcinoma	GDSC	VRSTPEGS	DEG_SCF_FBW7_1	0.8301
p.R64C	HT-115	large_intestine	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	0.8301
p.S76F	ACH-000882	Skin Cancer	CCLE	VRSTPEGS	DEG_SCF_FBW7_1	0.1389
p.S76F	IGR-1	skin	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	0.1389
p.R63C	ACH-000986	Colon/Colorectal Cancer	CCLE	VRSTPEGS	DEG_SCF_FBW7_1	0.719
p.R63C	HT-115	large_intestine	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	0.719
p.R62C	HT-115	large_intestine	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	0.8301
p.S75F	IGR-1	skin	COSMIC	VRSTPEGS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35557	Hexokinase-4	DEG_SCF_FBW7_1	62:69	VRSTPEGS	FBXW7	0.8507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons