DegronMD - P35573(AGL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C1373S	TCGA-3Z-A93Z	KIRC	TCGA	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.0833
p.C1373S	DO219229	KIRC	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.0833
p.D1364G	TCGA-77-A5GH	LUSC	TCGA	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation altering degron motif	0.7198
p.D1364G	DO45452	LUSC	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation altering degron motif	0.7198
p.A1368V	TCGA-BR-7707	STAD	TCGA	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.2222
p.A1368V	DO38487	STAD	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.2222
p.W1372L	DO229037	LICA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.1111
p.V1356F	DO229045	LICA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.2778
p.P1371S	DO220856	MELA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.1389
p.R1359C	DO222494	MELA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation altering degron motif	0.719
p.D1364H	SIDM00995	Other Solid Cancers	GDSC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation altering degron motif	0.7688
p.D1364H	ACH-001328	Skin Cancer	CCLE	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation altering degron motif	0.7688
p.D1364H	A431	skin	COSMIC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation altering degron motif	0.7688
p.Y1362C	ACH-001719	Ovarian Cancer	CCLE	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation altering degron motif	0.7087
p.T1366I	NCI-H2135	lung	COSMIC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.2778
p.D1348H	A431	skin	COSMIC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	1358:1364	Mutation rewiring degron network	0.0556

Kaplan plot for AGL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGL

UniProt ID: P35573

Entrez ID: 178

Protein name: Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGL in