DegronMD

Uniprot ID: P35573

Source protein: Glycogen debranching enzyme

Source gene: AGL

Class: LIG_APCC_ABBAyCdc20_2

Location: 1358:1364

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6303

ASA_SCORE: 45.8714

COIL: 0.5534

CONS_SCORE: 0.6004

DSS_SCORE: 0.3134

HELIX: 0.086

FCONS_SCORE: 1.4901

RIG_SCORE: 0.7651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1373S	TCGA-3Z-A93Z	KIRC	TCGA	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.C1373S	DO219229	KIRC	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D1364G	TCGA-77-A5GH	LUSC	TCGA	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.7198
p.D1364G	DO45452	LUSC	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.7198
p.A1368V	TCGA-BR-7707	STAD	TCGA	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A1368V	DO38487	STAD	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.W1372L	DO229037	LICA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V1356F	DO229045	LICA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1371S	DO220856	MELA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R1359C	DO222494	MELA	ICGC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.719
p.D1364H	SIDM00995	Other Solid Cancers	GDSC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D1364H	ACH-001328	Skin Cancer	CCLE	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D1364H	A431	skin	COSMIC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.7688
p.Y1362C	ACH-001719	Ovarian Cancer	CCLE	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.7087
p.T1366I	NCI-H2135	lung	COSMIC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1348H	A431	skin	COSMIC	KRGIYKD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35573	Glycogen debranching enzyme	LIG_APCC_ABBAyCdc20_2	1358:1364	KRGIYKD	APC,CDC20,FZR1	0.6303	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons