DegronMD - P35579(MYH9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1916F	TCGA-21-5783	LUSC	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation blocking phosphorylation signal	0.6111
p.S1916F	TCGA-XV-A9VZ	SKCM	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation blocking phosphorylation signal	0.6111
p.S1916F	DO27437	LUSC	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation blocking phosphorylation signal	0.6111
p.S1916F	DO219489	SKCM	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation blocking phosphorylation signal	0.6111
p.R1912C	TCGA-A5-A0GB	UCEC	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.R1912C	DO41434	UCEC	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.R1912H	TCGA-AA-A010	COAD	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.R1912H	TCGA-D1-A16R	UCEC	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.R1912H	DO41831	UCEC	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.R1936Q	TCGA-HU-A4G8	STAD	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.1667
p.R1936Q	DO233903	GACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.1667
p.R1936Q	DO47819	STAD	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.1667
p.R1932H	DO227657	COCA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.2778
p.R1932C	DO233143	GACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.2778
p.A1939T	DO233882	GACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0833
p.V1930M	DO35478	PACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation altering degron motif	0.6097
p.G1940R	SIDM00284	Melanoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.G1940R	SIDM00272	Breast Carcinoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.G1940R	SIDM01128	Small Cell Lung Carcinoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556
p.G1940R	SIDM01739	Small Cell Lung Carcinoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	1922:1930	Mutation rewiring degron network	0.0556

Kaplan plot for MYH9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYH9

UniProt ID: P35579

Entrez ID: 4627

Protein name: Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYH9 in