DegronMD

Uniprot ID: P35579

Source protein: Myosin-9

Source gene: MYH9

Class: DEG_APCC_DBOX_1

Location: 1922:1930

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9026

ASA_SCORE: 101.2778

COIL: 0.8039

CONS_SCORE: 0.2588

DSS_SCORE: 0.4677

HELIX: 0.1796

FCONS_SCORE: 0.9325

RIG_SCORE: 0.7604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1916F	TCGA-21-5783	LUSC	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	0.6111
p.S1916F	TCGA-XV-A9VZ	SKCM	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	0.6111
p.S1916F	DO27437	LUSC	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.6111
p.S1916F	DO219489	SKCM	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.6111
p.R1912C	TCGA-A5-A0GB	UCEC	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.R1912C	DO41434	UCEC	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.R1912H	TCGA-AA-A010	COAD	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.R1912H	TCGA-D1-A16R	UCEC	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.R1912H	DO41831	UCEC	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.R1936Q	TCGA-HU-A4G8	STAD	TCGA	RRGDLPFVV	DEG_APCC_DBOX_1	0.1667
p.R1936Q	DO233903	GACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.1667
p.R1936Q	DO47819	STAD	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.1667
p.R1932H	DO227657	COCA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.2778
p.R1932C	DO233143	GACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.2778
p.A1939T	DO233882	GACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.0833
p.V1930M	DO35478	PACA	ICGC	RRGDLPFVV	DEG_APCC_DBOX_1	0.6097
p.G1940R	SIDM00284	Melanoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.G1940R	SIDM00272	Breast Carcinoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.G1940R	SIDM01128	Small Cell Lung Carcinoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556
p.G1940R	SIDM01739	Small Cell Lung Carcinoma	GDSC	RRGDLPFVV	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35579	Myosin-9	DEG_APCC_DBOX_1	1922:1930	RRGDLPFVV	APC,CDC20,FZR1	0.9026	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons