DegronMD - P35606(COPB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N834H	TCGA-B8-5552	KIRC	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.2778
p.E831K	TCGA-BT-A42F	BLCA	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.591
p.D841Y	TCGA-CG-4306	STAD	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.0833
p.P825S	TCGA-HC-A6AL	PRAD	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.6752
p.D841H	TCGA-UY-A78L	BLCA	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.0833
p.E832D	TCGA-UY-A78L	BLCA	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.6758
p.G826V	DO14766	HNSC	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.7532
p.T832N	DO228971	LICA	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.7055
p.P815T	DO229006	LICA	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.0556
p.P815H	DO229009	LICA	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.0556
p.G826R	DO31070	OV	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.7568
p.G826E	DO42673	UCEC	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.7199
p.E823K	HSC-3	upper aerodigestive tract	COSMIC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.2778
p.A837V	FTC-133	thyroid	COSMIC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.1944
p.P833L	SNU-1040	large intestine	COSMIC	PLVTPNEE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons