DegronMD

Uniprot ID: P35606

Source protein: Coatomer subunit beta'

Source gene: COPB2

Class: DEG_SCF_FBW7_2

Location: 825:832

E3 ligase: FBXW7

DEGRON score: 0.9773

ASA_SCORE: 83.2125

COIL: 0.8141

CONS_SCORE: 0.2293

DSS_SCORE: 0.4955

HELIX: 0.1451

FCONS_SCORE: 0.93

RIG_SCORE: 0.7479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N834H	TCGA-B8-5552	KIRC	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	0.2778
p.E831K	TCGA-BT-A42F	BLCA	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	0.591
p.D841Y	TCGA-CG-4306	STAD	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	0.0833
p.P825S	TCGA-HC-A6AL	PRAD	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	0.6752
p.D841H	TCGA-UY-A78L	BLCA	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	0.0833
p.E832D	TCGA-UY-A78L	BLCA	TCGA	PLVTPNEE	DEG_SCF_FBW7_2	0.6758
p.G826V	DO14766	HNSC	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	0.7532
p.T832N	DO228971	LICA	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	0.7055
p.P815T	DO229006	LICA	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	0.0556
p.P815H	DO229009	LICA	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	0.0556
p.G826R	DO31070	OV	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	0.7568
p.G826E	DO42673	UCEC	ICGC	PLVTPNEE	DEG_SCF_FBW7_2	0.7199
p.E823K	HSC-3	upper_aerodigestive_tract	COSMIC	PLVTPNEE	DEG_SCF_FBW7_2	0.2778
p.A837V	FTC-133	thyroid	COSMIC	PLVTPNEE	DEG_SCF_FBW7_2	0.1944
p.P833L	SNU-1040	large_intestine	COSMIC	PLVTPNEE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35606	Coatomer subunit beta'	DEG_SCF_FBW7_2	825:832	PLVTPNEE	FBXW7	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons