DegronMD - P35613(BSG)

FUNCTION: [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11943775, PubMed:11688976). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:12553375, PubMed:11992541, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G308S	TCGA-B5-A0JN	UCEC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.0556
p.G308S	TCGA-WE-AAA3	SKCM	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.0556
p.V332M	TCGA-EO-A22U	UCEC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.1667
p.A324V	TCGA-FI-A2D0	UCEC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation altering degron motif	0.5825
p.A323V	TCGA-G4-6302	COAD	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation altering degron motif	0.5825
p.E334K	TCGA-JW-A5VL	CESC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.1111
p.A312T	TCGA-QH-A65S	LGG	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.1667
p.R317C	SIDM00770	Small Cell Lung Carcinoma	GDSC	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.3056
p.R317C	ACH-000559	Lung Cancer	CCLE	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.3056
p.R317C	NCI-H1836	lung	COSMIC	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation rewiring degron network	0.3056
p.S320N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation altering degron motif	0.5958
p.S320N	ACH-001127	Leukemia	CCLE	VRSHLAALW	DEG_APCC_DBOX_1	318:326	Mutation altering degron motif	0.5958

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BSG

UniProt ID: P35613

Entrez ID: 682

Protein name: Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BSG in