DegronMD

Uniprot ID: P35613

Source protein: Basigin

Source gene: BSG

Class: DEG_APCC_DBOX_1

Location: 318:326

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.875

ASA_SCORE: 76.8667

COIL: 0.5388

CONS_SCORE: 0.7405

DSS_SCORE: 0.0089

HELIX: 0.1179

FCONS_SCORE: 1.1114

RIG_SCORE: 0.9262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G308S	TCGA-B5-A0JN	UCEC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	0.0556
p.G308S	TCGA-WE-AAA3	SKCM	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	0.0556
p.V332M	TCGA-EO-A22U	UCEC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	0.1667
p.A324V	TCGA-FI-A2D0	UCEC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	0.5825
p.A323V	TCGA-G4-6302	COAD	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	0.5825
p.E334K	TCGA-JW-A5VL	CESC	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	0.1111
p.A312T	TCGA-QH-A65S	LGG	TCGA	VRSHLAALW	DEG_APCC_DBOX_1	0.1667
p.R317C	SIDM00770	Small Cell Lung Carcinoma	GDSC	VRSHLAALW	DEG_APCC_DBOX_1	0.3056
p.R317C	ACH-000559	Lung Cancer	CCLE	VRSHLAALW	DEG_APCC_DBOX_1	0.3056
p.R317C	NCI-H1836	lung	COSMIC	VRSHLAALW	DEG_APCC_DBOX_1	0.3056
p.S320N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VRSHLAALW	DEG_APCC_DBOX_1	0.5958
p.S320N	ACH-001127	Leukemia	CCLE	VRSHLAALW	DEG_APCC_DBOX_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35613	Basigin	DEG_APCC_DBOX_1	318:326	VRSHLAALW	APC,CDC20,FZR1	0.875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons