DegronMD - P35663(CYLC1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A158E	TCGA-66-2727	LUSC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.659
p.A158E	DO26478	LUSC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.659
p.N156K	TCGA-A6-5665	COAD	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.3056
p.N156K	DO9756	COAD	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.3056
p.E150D	TCGA-AG-3892	READ	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1389
p.E150D	DO36394	READ	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1389
p.K173M	TCGA-BS-A0TI	UCEC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation substituting flanking lysine	0.1944
p.K173M	DO41608	UCEC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation substituting flanking lysine	0.1944
p.D159N	TCGA-C5-A8YQ	CESC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.6932
p.D159N	DO49906	CESC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.6932
p.E168K	TCGA-EE-A3J5	SKCM	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.2222
p.E168K	DO47331	SKCM	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.2222
p.E149D	TCGA-EO-A3AV	UCEC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1111
p.E149D	DO52412	UCEC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1111
p.K173R	DO50385	ESAD	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation substituting flanking lysine	0.1944
p.K173R	DO228732	GACA	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation substituting flanking lysine	0.1944
p.T152P	DO233894	GACA	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1944
p.E157D	DO229036	LICA	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.5647
p.P162S	DO229177	LMS	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.6752
p.K164N	DO229162	NKTL	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.6918
p.Q171K	SIDM01001	Breast Carcinoma	GDSC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1389
p.Q171K	ACH-000258	Breast Cancer	CCLE	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1389
p.Q171K	DU-4475	breast	COSMIC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.1389
p.T161A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.825
p.T161A	ACH-000942	Leukemia	CCLE	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation altering degron motif	0.825
p.R154T	ACH-001147	Lymphoma	CCLE	EADKTPLK	DEG_SCF_SKP2-CKS1_1	157:164	Mutation rewiring degron network	0.25

Kaplan plot for CYLC1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CYLC1

UniProt ID: P35663

Entrez ID: 1538

Protein name: Cylicin-1 (Cylicin I) (Multiple-band polypeptide I)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CYLC1 in