DegronMD

Uniprot ID: P35663

Source protein: Cylicin-1

Source gene: CYLC1

Class: DEG_SCF_SKP2-CKS1_1

Location: 157:164

E3 ligase: SKP2,CSK1

DEGRON score: 0.9996

ASA_SCORE: 108.8875

COIL: 0.8091

CONS_SCORE: 0.514

DSS_SCORE: 0.7481

HELIX: 0.1694

FCONS_SCORE: 1.2573

RIG_SCORE: 0.6272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A158E	TCGA-66-2727	LUSC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.659
p.A158E	DO26478	LUSC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.659
p.N156K	TCGA-A6-5665	COAD	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.N156K	DO9756	COAD	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E150D	TCGA-AG-3892	READ	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E150D	DO36394	READ	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.K173M	TCGA-BS-A0TI	UCEC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.K173M	DO41608	UCEC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D159N	TCGA-C5-A8YQ	CESC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D159N	DO49906	CESC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.6932
p.E168K	TCGA-EE-A3J5	SKCM	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E168K	DO47331	SKCM	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E149D	TCGA-EO-A3AV	UCEC	TCGA	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E149D	DO52412	UCEC	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.K173R	DO50385	ESAD	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.K173R	DO228732	GACA	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.T152P	DO233894	GACA	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E157D	DO229036	LICA	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.5647
p.P162S	DO229177	LMS	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.6752
p.K164N	DO229162	NKTL	ICGC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.6918
p.Q171K	SIDM01001	Breast Carcinoma	GDSC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.Q171K	ACH-000258	Breast Cancer	CCLE	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.Q171K	DU-4475	breast	COSMIC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T161A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.825
p.T161A	ACH-000942	Leukemia	CCLE	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.825
p.R154T	ACH-001147	Lymphoma	CCLE	EADKTPLK	DEG_SCF_SKP2-CKS1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35663	Cylicin-1	DEG_SCF_SKP2-CKS1_1	157:164	EADKTPLK	SKP2,CSK1	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EADKTPLK

Degron related mutations and impact score

Drug responses associated with CYLC1 mutations

All proteins holding degron of EADKTPLK