DegronMD - P35670(ATP7B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T9R	TCGA-55-8094	LUAD	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation blocking phosphorylation signal	0.6111
p.T9R	DO24150	LUAD	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation blocking phosphorylation signal	0.6111
p.R27C	TCGA-D1-A167	UCEC	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2222
p.R27C	TCGA-FW-A3R5	SKCM	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2222
p.R27C	DO37406	SKCM	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2222
p.R27C	DO40978	UCEC	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2222
p.E5Q	TCGA-K4-A54R	BLCA	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation substituting flanking lysine	0.1667
p.E5Q	DO48611	BLCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation substituting flanking lysine	0.1667
p.E30K	TCGA-VR-A8EW	ESCA	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1389
p.S20F	TCGA-W3-AA1R	SKCM	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6871
p.S20F	DO51275	SKCM	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6871
p.M33I	DO218173	BRCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.V6F	DO1749	BRCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.S23C	DO233262	GACA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7541
p.L20M	DO229018	LICA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.711
p.A10S	DO232224	PBCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1944
p.S20Y	SIDM00777	Colorectal Carcinoma	GDSC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6009
p.S20Y	ACH-000360	Colon/Colorectal Cancer	CCLE	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6009
p.S20Y	NCI-H508	large intestine	COSMIC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6009
p.Q7E	SIDM00919	Ovarian Carcinoma	GDSC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.E12D	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.25
p.E12D	ACH-000945	Lung Cancer	CCLE	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.25
p.E12D	NCI-H650	lung	COSMIC	SRKILSKLS	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.25

Kaplan plot for ATP7B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP7B

UniProt ID: P35670

Entrez ID: 540

Protein name: Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP7B in