DegronMD

Uniprot ID: P35670

Source protein: Copper-transporting ATPase 2

Source gene: ATP7B

Class: DEG_APCC_DBOX_1

Location: 15:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9848

ASA_SCORE: 79.3444

COIL: 0.4871

CONS_SCORE: -666.6301

DSS_SCORE: 0.4084

HELIX: 0.2452

FCONS_SCORE: 1.6298

RIG_SCORE: 0.7634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T9R	TCGA-55-8094	LUAD	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	0.6111
p.T9R	DO24150	LUAD	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.6111
p.R27C	TCGA-D1-A167	UCEC	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	0.2222
p.R27C	TCGA-FW-A3R5	SKCM	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	0.2222
p.R27C	DO37406	SKCM	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.2222
p.R27C	DO40978	UCEC	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.2222
p.E5Q	TCGA-K4-A54R	BLCA	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	0.1667
p.E5Q	DO48611	BLCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.1667
p.E30K	TCGA-VR-A8EW	ESCA	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	0.1389
p.S20F	TCGA-W3-AA1R	SKCM	TCGA	SRKILSKLS	DEG_APCC_DBOX_1	0.6871
p.S20F	DO51275	SKCM	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.6871
p.M33I	DO218173	BRCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.0556
p.V6F	DO1749	BRCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.0833
p.S23C	DO233262	GACA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.7541
p.L20M	DO229018	LICA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.711
p.A10S	DO232224	PBCA	ICGC	SRKILSKLS	DEG_APCC_DBOX_1	0.1944
p.S20Y	SIDM00777	Colorectal Carcinoma	GDSC	SRKILSKLS	DEG_APCC_DBOX_1	0.6009
p.S20Y	ACH-000360	Colon/Colorectal Cancer	CCLE	SRKILSKLS	DEG_APCC_DBOX_1	0.6009
p.S20Y	NCI-H508	large_intestine	COSMIC	SRKILSKLS	DEG_APCC_DBOX_1	0.6009
p.Q7E	SIDM00919	Ovarian Carcinoma	GDSC	SRKILSKLS	DEG_APCC_DBOX_1	0.1111
p.E12D	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	SRKILSKLS	DEG_APCC_DBOX_1	0.25
p.E12D	ACH-000945	Lung Cancer	CCLE	SRKILSKLS	DEG_APCC_DBOX_1	0.25
p.E12D	NCI-H650	lung	COSMIC	SRKILSKLS	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35670	Copper-transporting ATPase 2	DEG_APCC_DBOX_1	15:23	SRKILSKLS	APC,CDC20,FZR1	0.9848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons