DegronMD - P35711(SOX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D172N	TCGA-21-1079	LUSC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1667
p.M151I	TCGA-60-2722	LUSC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1111
p.M151I	TCGA-FX-A76Y	SARC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1111
p.E158Q	TCGA-BT-A3PH	BLCA	TCGA	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.3056
p.E153Q	TCGA-CV-6942	HNSC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1667
p.S169L	DO51634	CESC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.25
p.S169L	DO220172	SARC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.25
p.G170W	DO10044	COAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.2222
p.L155P	DO50439	ESAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.2222
p.K158T	DO50345	ESAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.3056
p.L155Q	DO233696	GACA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.2222
p.A166E	DO228948	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.7701
p.D159E	DO229019	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6758
p.E153K	DO50826	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1667
p.T149A	DO230931	LUSC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.0556
p.T149A	DO224548	LUSC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.0556
p.D159N	DO26846	LUSC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6932
p.L164P	DO232038	ORCA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.7582
p.D162N	DO218280	ORCA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6932
p.D162N	ACH-001200	Rhabdoid	CCLE	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6932
p.D162N	H9	haematopoietic and lymphoid tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6932
p.N171T	DO47719	STAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation blocking ubiquitination signal	0.6389
p.G168R	DO41361	UCEC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.2778
p.D175N	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.0833
p.D175N	H9	haematopoietic and lymphoid tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.0833
p.L154I	SIDM00889	Cervical Carcinoma	GDSC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1944
p.L154I	ACH-001333	Cervical Cancer	CCLE	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1944
p.L154I	C-33-A	cervix	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.1944
p.D165N	ACH-000509	Lymphoma	CCLE	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6932
p.D165N	ACH-002240	Lymphoma	CCLE	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6932
p.D165N	H9	haematopoietic and lymphoid tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.6932
p.S176N	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation substituting flanking lysine	0.1667
p.R155S	TYK-nu	ovary	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation rewiring degron network	0.2222
p.R161Q	CAL-27	upper aerodigestive tract	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	159:166	Mutation altering degron motif	0.7329

Kaplan plot for SOX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX5

UniProt ID: P35711

Entrez ID: 6660

Protein name: Transcription factor SOX-5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX5 in