DegronMD

Uniprot ID: P35711

Source protein: Transcription factor SOX-5

Source gene: SOX5

Class: DEG_SCF_FBW7_2

Location: 159:166

E3 ligase: FBXW7

DEGRON score: 0.8966

ASA_SCORE: 90.55

COIL: 0.5728

CONS_SCORE: 0.3749

DSS_SCORE: 0.4864

HELIX: 0.4135

FCONS_SCORE: 1.0706

RIG_SCORE: 0.7468

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D172N	TCGA-21-1079	LUSC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	0.1667
p.M151I	TCGA-60-2722	LUSC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	0.1111
p.M151I	TCGA-FX-A76Y	SARC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	0.1111
p.E158Q	TCGA-BT-A3PH	BLCA	TCGA	PEETPSIE	DEG_SCF_FBW7_2	0.3056
p.E153Q	TCGA-CV-6942	HNSC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	0.1667
p.S169L	DO51634	CESC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.25
p.S169L	DO220172	SARC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.25
p.G170W	DO10044	COAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.L155P	DO50439	ESAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.K158T	DO50345	ESAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.3056
p.L155Q	DO233696	GACA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.A166E	DO228948	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.7701
p.D159E	DO229019	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6758
p.E153K	DO50826	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.1667
p.T149A	DO230931	LUSC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.0556
p.T149A	DO224548	LUSC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.0556
p.D159N	DO26846	LUSC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.L164P	DO232038	ORCA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.7582
p.D162N	DO218280	ORCA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D162N	ACH-001200	Rhabdoid	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D162N	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.N171T	DO47719	STAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6389
p.G168R	DO41361	UCEC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2778
p.D175N	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PEETPSIE	DEG_SCF_FBW7_2	0.0833
p.D175N	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.0833
p.L154I	SIDM00889	Cervical Carcinoma	GDSC	PEETPSIE	DEG_SCF_FBW7_2	0.1944
p.L154I	ACH-001333	Cervical Cancer	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.1944
p.L154I	C-33-A	cervix	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.1944
p.D165N	ACH-000509	Lymphoma	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D165N	ACH-002240	Lymphoma	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D165N	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.S176N	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.1667
p.R155S	TYK-nu	ovary	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.R161Q	CAL-27	upper_aerodigestive_tract	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEETPSIE

Degron related mutations and impact score

Drug responses associated with SOX5 mutations

All proteins holding degron of PEETPSIE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35711	Transcription factor SOX-5	DEG_SCF_FBW7_2	159:166	PEETPSIE	FBXW7	0.8966	More...