DegronMD

Uniprot ID: P35711

Source protein: Transcription factor SOX-5

Source gene: SOX5

Class: DEG_SCF_FBW7_2

Location: 159:166

E3 ligase: FBXW7

DEGRON score: 0.8966

ASA_SCORE: 90.55

COIL: 0.5728

CONS_SCORE: 0.3749

DSS_SCORE: 0.4864

HELIX: 0.4135

FCONS_SCORE: 1.0706

RIG_SCORE: 0.7468

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A166E	DO228948	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.7701
p.L164P	DO232038	ORCA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.7582
p.R161Q	CAL-27	upper_aerodigestive_tract	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.7329
p.D159N	DO26846	LUSC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D162N	DO218280	ORCA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D162N	ACH-001200	Rhabdoid	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D162N	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D165N	ACH-000509	Lymphoma	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D165N	ACH-002240	Lymphoma	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D165N	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.6932
p.D159E	DO229019	LICA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6758
p.N171T	DO47719	STAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.6389
p.E158Q	TCGA-BT-A3PH	BLCA	TCGA	PEETPSIE	DEG_SCF_FBW7_2	0.3056
p.K158T	DO50345	ESAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.3056
p.G168R	DO41361	UCEC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2778
p.S169L	DO51634	CESC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.25
p.S169L	DO220172	SARC	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.25
p.G170W	DO10044	COAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.L155P	DO50439	ESAD	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.L155Q	DO233696	GACA	ICGC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.R155S	TYK-nu	ovary	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.2222
p.L154I	SIDM00889	Cervical Carcinoma	GDSC	PEETPSIE	DEG_SCF_FBW7_2	0.1944
p.L154I	ACH-001333	Cervical Cancer	CCLE	PEETPSIE	DEG_SCF_FBW7_2	0.1944
p.L154I	C-33-A	cervix	COSMIC	PEETPSIE	DEG_SCF_FBW7_2	0.1944
p.D172N	TCGA-21-1079	LUSC	TCGA	PEETPSIE	DEG_SCF_FBW7_2	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35711	Transcription factor SOX-5	DEG_SCF_FBW7_2	159:166	PEETPSIE	FBXW7	0.8966	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons