DegronMD - P35749(MYH11)

MYH11

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1791D	TCGA-32-2495	GBM	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation rewiring degron network	0.1667
p.A1787T	TCGA-CG-5723	STAD	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation rewiring degron network	0.0556
p.G1813R	TCGA-D3-A8GI	SKCM	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation substituting flanking lysine	0.2222
p.R1794W	TCGA-FI-A2D0	UCEC	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation rewiring degron network	0.25
p.E1803K	TCGA-W3-AA1R	SKCM	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation altering degron motif	0.591
p.G1806R	DO50284	SKCM	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation rewiring degron network	0.3056
p.E1796K	DO51275	SKCM	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation rewiring degron network	0.3056
p.K1811E	DO38123	SKCM	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation substituting flanking lysine	0.2778
p.R1787W	DO43891	UCEC	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation rewiring degron network	0.0556
p.R1799Q	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation altering degron motif	0.7329
p.R1792Q	ACH-000388	Lymphoma	CCLE	LRSKLHEME	DEG_APCC_DBOX_1	1797:1805	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc