DegronMD

Uniprot ID: P35749

Source protein: Myosin-11

Source gene: MYH11

Class: DEG_APCC_DBOX_1

Location: 1797:1805

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6417

ASA_SCORE: 90.1

COIL: 0.0231

CONS_SCORE: 0.4108

DSS_SCORE: 0.5337

HELIX: 0.9779

FCONS_SCORE: 1.1156

RIG_SCORE: 0.7073

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1799Q	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRSKLHEME	DEG_APCC_DBOX_1	0.7329
p.E1803K	TCGA-W3-AA1R	SKCM	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	0.591
p.G1806R	DO50284	SKCM	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	0.3056
p.E1796K	DO51275	SKCM	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	0.3056
p.K1811E	DO38123	SKCM	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	0.2778
p.R1794W	TCGA-FI-A2D0	UCEC	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	0.25
p.G1813R	TCGA-D3-A8GI	SKCM	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	0.2222
p.R1792Q	ACH-000388	Lymphoma	CCLE	LRSKLHEME	DEG_APCC_DBOX_1	0.1944
p.E1791D	TCGA-32-2495	GBM	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	0.1667
p.A1787T	TCGA-CG-5723	STAD	TCGA	LRSKLHEME	DEG_APCC_DBOX_1	0.0556
p.R1787W	DO43891	UCEC	ICGC	LRSKLHEME	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35749	Myosin-11	DEG_APCC_DBOX_1	1797:1805	LRSKLHEME	APC,CDC20,FZR1	0.6417	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons