DegronMD - P36402(TCF7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S193Y	TCGA-06-5416	GBM	TCGA	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation altering degron motif	0.712
p.A182S	DO222783	BTCA	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.2222
p.G189D	DO233782	GACA	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation altering degron motif	0.7198
p.Q200H	DO229037	LICA	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.1389
p.I187F	DO223711	PAAD	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation altering degron motif	0.7415
p.A201V	DO42977	UCEC	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.1111
p.S196P	DO41999	UCEC	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.25
p.D177A	SIDM00600	Thyroid Gland Carcinoma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.0833
p.D177A	SIDM01573	Plasma Cell Myeloma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.0833
p.D177A	ACH-000576	Myeloma	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.0833
p.D177A	ACH-001528	Thyroid Cancer	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.0833
p.D177A	IHH-4	thyroid	COSMIC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.0833
p.S179I	SIDM00544	Neuroblastoma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation blocking phosphorylation signal	0.5833
p.S179I	ACH-001716	Neuroblastoma	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation blocking phosphorylation signal	0.5833
p.S179I	GOTO	autonomic ganglia	COSMIC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation blocking phosphorylation signal	0.5833
p.I178V	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.1111
p.I178V	ACH-000744	Lung Cancer	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.1111
p.I178V	NCI-H1623	lung	COSMIC	PLQTPDLS	DEG_SCF_FBW7_1	186:193	Mutation rewiring degron network	0.1111

Kaplan plot for TCF7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF7

UniProt ID: P36402

Entrez ID: 6932

Protein name: Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF7 in