DegronMD

Uniprot ID: P36402

Source protein: Transcription factor 7

Source gene: TCF7

Class: DEG_SCF_FBW7_1

Location: 186:193

E3 ligase: FBXW7

DEGRON score: 0.918

ASA_SCORE: 62.9875

COIL: 0.8518

CONS_SCORE: 0.4538

DSS_SCORE: 0.4741

HELIX: 0.0982

FCONS_SCORE: 0.9256

RIG_SCORE: 0.71

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S193Y	TCGA-06-5416	GBM	TCGA	PLQTPDLS	DEG_SCF_FBW7_1	0.712
p.A182S	DO222783	BTCA	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	0.2222
p.G189D	DO233782	GACA	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	0.7198
p.Q200H	DO229037	LICA	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	0.1389
p.I187F	DO223711	PAAD	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	0.7415
p.A201V	DO42977	UCEC	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	0.1111
p.S196P	DO41999	UCEC	ICGC	PLQTPDLS	DEG_SCF_FBW7_1	0.25
p.D177A	SIDM00600	Thyroid Gland Carcinoma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	0.0833
p.D177A	SIDM01573	Plasma Cell Myeloma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	0.0833
p.D177A	ACH-000576	Myeloma	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	0.0833
p.D177A	ACH-001528	Thyroid Cancer	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	0.0833
p.D177A	IHH-4	thyroid	COSMIC	PLQTPDLS	DEG_SCF_FBW7_1	0.0833
p.S179I	SIDM00544	Neuroblastoma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	0.5833
p.S179I	ACH-001716	Neuroblastoma	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	0.5833
p.S179I	GOTO	autonomic_ganglia	COSMIC	PLQTPDLS	DEG_SCF_FBW7_1	0.5833
p.I178V	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PLQTPDLS	DEG_SCF_FBW7_1	0.1111
p.I178V	ACH-000744	Lung Cancer	CCLE	PLQTPDLS	DEG_SCF_FBW7_1	0.1111
p.I178V	NCI-H1623	lung	COSMIC	PLQTPDLS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36402	Transcription factor 7	DEG_SCF_FBW7_1	186:193	PLQTPDLS	FBXW7	0.918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons