DegronMD - P36544(CHRNA7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R373Q	TCGA-A5-A0G2	UCEC	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	TCGA-CM-6674	COAD	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	TCGA-D3-A5GO	SKCM	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	TCGA-DD-AAE2	LIHC	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	TCGA-F5-6814	READ	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	DO10092	COAD	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	DO52256	LIHC	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	DO36556	READ	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	DO47419	SKCM	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.R373Q	DO41235	UCEC	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.C368Y	TCGA-AX-A2HA	UCEC	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation altering degron motif	0.7087
p.C368Y	DO42504	UCEC	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation altering degron motif	0.7087
p.D352N	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation substituting flanking lysine	0.1667
p.A373T	ACH-000094	Pancreatic Cancer	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.A373T	HPAF-II	pancreas	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.25
p.A375V	ACH-000198	Leukemia	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.1944
p.C357R	ACH-000833	Sarcoma	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.1944
p.C357R	SJRH30	soft tissue	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.1944
p.M371I	ACH-000871	Lung Cancer	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.3056
p.M371I	NCI-H510A	lung	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.3056
p.V374M	ACH-002222	Leukemia	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.2222
p.V374M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.2222
p.R362W	ACH-002305	Head and Neck Cancer	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation altering degron motif	0.7523
p.R362W	SKN-3	upper aerodigestive tract	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation altering degron motif	0.7523
p.P376L	YT	haematopoietic and lymphoid tissue	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.1667
p.S372N	CHP-134	autonomic ganglia	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	362:370	Mutation rewiring degron network	0.2778

Kaplan plot for CHRNA7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHRNA7

UniProt ID: P36544

Entrez ID: 1139

Protein name: Neuronal acetylcholine receptor subunit alpha-7

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHRNA7 in