DegronMD

Uniprot ID: P36544

Source protein: Neuronal acetylcholine receptor subunit alpha-7

Source gene: CHRNA7

Class: DEG_APCC_DBOX_1

Location: 362:370

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7239

ASA_SCORE: 91.6556

COIL: 0.6736

CONS_SCORE: 0.4218

DSS_SCORE: 0.2943

HELIX: 0.2673

FCONS_SCORE: 1.2098

RIG_SCORE: 0.7532

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R373Q	TCGA-A5-A0G2	UCEC	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	TCGA-CM-6674	COAD	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	TCGA-D3-A5GO	SKCM	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	TCGA-DD-AAE2	LIHC	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	TCGA-F5-6814	READ	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	DO10092	COAD	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	DO52256	LIHC	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	DO36556	READ	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	DO47419	SKCM	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.R373Q	DO41235	UCEC	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.C368Y	TCGA-AX-A2HA	UCEC	TCGA	RRCSLASVE	DEG_APCC_DBOX_1	0.7087
p.C368Y	DO42504	UCEC	ICGC	RRCSLASVE	DEG_APCC_DBOX_1	0.7087
p.D352N	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	RRCSLASVE	DEG_APCC_DBOX_1	0.1667
p.A373T	ACH-000094	Pancreatic Cancer	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.A373T	HPAF-II	pancreas	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	0.25
p.A375V	ACH-000198	Leukemia	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	0.1944
p.C357R	ACH-000833	Sarcoma	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	0.1944
p.C357R	SJRH30	soft_tissue	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	0.1944
p.M371I	ACH-000871	Lung Cancer	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	0.3056
p.M371I	NCI-H510A	lung	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	0.3056
p.V374M	ACH-002222	Leukemia	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	0.2222
p.V374M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	0.2222
p.R362W	ACH-002305	Head and Neck Cancer	CCLE	RRCSLASVE	DEG_APCC_DBOX_1	0.7523
p.R362W	SKN-3	upper_aerodigestive_tract	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	0.7523
p.P376L	YT	haematopoietic_and_lymphoid_tissue	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	0.1667
p.S372N	CHP-134	autonomic_ganglia	COSMIC	RRCSLASVE	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRCSLASVE

Degron related mutations and impact score

Drug responses associated with CHRNA7 mutations

All proteins holding degron of RRCSLASVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36544	Neuronal acetylcholine receptor subunit alpha-7	DEG_APCC_DBOX_1	362:370	RRCSLASVE	APC,CDC20,FZR1	0.7239	More...