DegronMD - P36941(LTBR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G398R	TCGA-A5-A0G2	UCEC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.3056
p.G398R	TCGA-B5-A0JY	UCEC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.3056
p.S400C	TCGA-CV-6961	HNSC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation altering degron motif	0.643
p.S400C	DO14566	HNSC	ICGC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation altering degron motif	0.643
p.K408N	TCGA-D5-6530	COAD	TCGA	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation substituting flanking lysine	0.3611
p.K408N	DO8312	COAD	ICGC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation substituting flanking lysine	0.3611
p.K408N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation substituting flanking lysine	0.3611
p.K408N	ACH-002256	Leukemia	CCLE	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation substituting flanking lysine	0.3611
p.K408N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation substituting flanking lysine	0.3611
p.A413V	TCGA-P3-A5QE	HNSC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1111
p.A394V	DO44418	HNSC	ICGC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1944
p.P394L	SIDM00857	Melanoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1944
p.P394L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1944
p.P394L	ACH-000572	Skin Cancer	CCLE	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1944
p.P394L	ACH-000583	Lymphoma	CCLE	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1944
p.P394L	G-361	skin	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1944
p.P394L	MC116	haematopoietic and lymphoid tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1944
p.H411D	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1667
p.H411D	ACH-000843	Lung Cancer	CCLE	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1667
p.H411D	HARA	lung	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1667
p.P397T	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.2778
p.P397T	ACH-000309	Lung Cancer	CCLE	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.2778
p.P397T	SK-LU-1	lung	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.2778
p.H392D	HARA	lung	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.1389
p.K389N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.0556
p.R409K	H9	haematopoietic and lymphoid tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	399:405	Mutation rewiring degron network	0.2222

Kaplan plot for LTBR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LTBR

UniProt ID: P36941

Entrez ID: 4055

Protein name: Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LTBR in