DegronMD

Uniprot ID: P36941

Source protein: Tumor necrosis factor receptor superfamily member 3

Source gene: LTBR

Class: DEG_SCF_FBW7_2

Location: 399:405

E3 ligase: FBXW7

DEGRON score: 0.9696

ASA_SCORE: 79.0857

COIL: 0.8071

CONS_SCORE: 0.6632

DSS_SCORE: 0.813

HELIX: 0.055

FCONS_SCORE: 1.0417

RIG_SCORE: 0.5652

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G398R	TCGA-A5-A0G2	UCEC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	0.3056
p.G398R	TCGA-B5-A0JY	UCEC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	0.3056
p.S400C	TCGA-CV-6961	HNSC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	0.643
p.S400C	DO14566	HNSC	ICGC	LSTPHQE	DEG_SCF_FBW7_2	0.643
p.K408N	TCGA-D5-6530	COAD	TCGA	LSTPHQE	DEG_SCF_FBW7_2	0.3611
p.K408N	DO8312	COAD	ICGC	LSTPHQE	DEG_SCF_FBW7_2	0.3611
p.K408N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LSTPHQE	DEG_SCF_FBW7_2	0.3611
p.K408N	ACH-002256	Leukemia	CCLE	LSTPHQE	DEG_SCF_FBW7_2	0.3611
p.K408N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.3611
p.A413V	TCGA-P3-A5QE	HNSC	TCGA	LSTPHQE	DEG_SCF_FBW7_2	0.1111
p.A394V	DO44418	HNSC	ICGC	LSTPHQE	DEG_SCF_FBW7_2	0.1944
p.P394L	SIDM00857	Melanoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	0.1944
p.P394L	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	0.1944
p.P394L	ACH-000572	Skin Cancer	CCLE	LSTPHQE	DEG_SCF_FBW7_2	0.1944
p.P394L	ACH-000583	Lymphoma	CCLE	LSTPHQE	DEG_SCF_FBW7_2	0.1944
p.P394L	G-361	skin	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.1944
p.P394L	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.1944
p.H411D	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	0.1667
p.H411D	ACH-000843	Lung Cancer	CCLE	LSTPHQE	DEG_SCF_FBW7_2	0.1667
p.H411D	HARA	lung	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.1667
p.P397T	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	LSTPHQE	DEG_SCF_FBW7_2	0.2778
p.P397T	ACH-000309	Lung Cancer	CCLE	LSTPHQE	DEG_SCF_FBW7_2	0.2778
p.P397T	SK-LU-1	lung	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.2778
p.H392D	HARA	lung	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.1389
p.K389N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.0556
p.R409K	H9	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPHQE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTPHQE

Degron related mutations and impact score

Drug responses associated with LTBR mutations

All proteins holding degron of LSTPHQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36941	Tumor necrosis factor receptor superfamily member 3	DEG_SCF_FBW7_2	399:405	LSTPHQE	FBXW7	0.9696	More...