DegronMD - P37802(TAGLN2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L167V	TCGA-85-7696	LUSC	TCGA	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1111
p.L167V	DO26671	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1111
p.K153N	TCGA-AP-A1DV	UCEC	TCGA	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation blocking ubiquitination signal	0.7222
p.K153N	DO43186	UCEC	ICGC	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation blocking ubiquitination signal	0.7222
p.P148H	TCGA-EE-A181	SKCM	TCGA	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1389
p.P148H	DO37444	SKCM	ICGC	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1389
p.D147N	DO228331	BRCA	ICGC	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1111
p.P159H	ACH-000343	Lung Cancer	CCLE	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6583
p.P159H	ACH-000982	Colon/Colorectal Cancer	CCLE	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6583
p.P159H	NCI-H522	lung	COSMIC	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6583
p.P159L	ACH-000939	Sarcoma	CCLE	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6471
p.P159L	SK-UT-1	soft tissue	COSMIC	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation altering degron motif	0.6471
p.N165Y	ACH-002147	Skin Cancer	CCLE	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1667
p.N165Y	K2	skin	COSMIC	SKENP	DEG_APCC_KENBOX_2	155:159	Mutation rewiring degron network	0.1667

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons