DegronMD

Uniprot ID: P37802

Source protein: Transgelin-2

Source gene: TAGLN2

Class: DEG_APCC_KENBOX_2

Location: 155:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9256

ASA_SCORE: 88

COIL: 0.8628

CONS_SCORE: 0.4264

DSS_SCORE: 0.6408

HELIX: 0.0898

FCONS_SCORE: 0.8945

RIG_SCORE: 0.6749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L167V	TCGA-85-7696	LUSC	TCGA	SKENP	DEG_APCC_KENBOX_2	0.1111
p.L167V	DO26671	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1111
p.K153N	TCGA-AP-A1DV	UCEC	TCGA	SKENP	DEG_APCC_KENBOX_2	0.7222
p.K153N	DO43186	UCEC	ICGC	SKENP	DEG_APCC_KENBOX_2	0.7222
p.P148H	TCGA-EE-A181	SKCM	TCGA	SKENP	DEG_APCC_KENBOX_2	0.1389
p.P148H	DO37444	SKCM	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1389
p.D147N	DO228331	BRCA	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1111
p.P159H	ACH-000343	Lung Cancer	CCLE	SKENP	DEG_APCC_KENBOX_2	0.6583
p.P159H	ACH-000982	Colon/Colorectal Cancer	CCLE	SKENP	DEG_APCC_KENBOX_2	0.6583
p.P159H	NCI-H522	lung	COSMIC	SKENP	DEG_APCC_KENBOX_2	0.6583
p.P159L	ACH-000939	Sarcoma	CCLE	SKENP	DEG_APCC_KENBOX_2	0.6471
p.P159L	SK-UT-1	soft_tissue	COSMIC	SKENP	DEG_APCC_KENBOX_2	0.6471
p.N165Y	ACH-002147	Skin Cancer	CCLE	SKENP	DEG_APCC_KENBOX_2	0.1667
p.N165Y	K2	skin	COSMIC	SKENP	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37802	Transgelin-2	DEG_APCC_KENBOX_2	155:159	SKENP	APC,CDC20,FZR1	0.9256	More...
Q15283	Ras GTPase-activating protein 2	DEG_APCC_KENBOX_2	840:844	SKENP	APC,CDC20,FZR1	0.9812	More...
Q8TBG4	Ethanolamine-phosphate phospho-lyase	DEG_APCC_KENBOX_2	474:478	SKENP	APC,CDC20,FZR1	0.828	More...
Q8N999	Uncharacterized protein C12orf29	DEG_APCC_KENBOX_2	96:100	SKENP	APC,CDC20,FZR1	0.6542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons