DegronMD

Uniprot ID: Q8N999

Source protein: Uncharacterized protein C12orf29

Source gene: C12orf29

Class: DEG_APCC_KENBOX_2

Location: 96:100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6542

ASA_SCORE: 93.52

COIL: 0.8558

CONS_SCORE: 0.5496

DSS_SCORE: 0.3092

HELIX: 0.1172

FCONS_SCORE: 0.7465

RIG_SCORE: 0.7064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K97N	TCGA-E6-A1LX	UCEC	TCGA	SKENP	DEG_APCC_KENBOX_2	0.6918
p.K97N	DO41020	UCEC	ICGC	SKENP	DEG_APCC_KENBOX_2	0.6918
p.F93V	TCGA-EO-A22X	UCEC	TCGA	SKENP	DEG_APCC_KENBOX_2	0.25
p.F93V	DO43907	UCEC	ICGC	SKENP	DEG_APCC_KENBOX_2	0.25
p.W105R	TCGA-IB-7651	PAAD	TCGA	SKENP	DEG_APCC_KENBOX_2	0.1944
p.W105R	DO46657	PAAD	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1944
p.R89K	DO233190	GACA	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1389
p.V107I	DO12382	GBM	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1389
p.W105G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SKENP	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37802	Transgelin-2	DEG_APCC_KENBOX_2	155:159	SKENP	APC,CDC20,FZR1	0.9256	More...
Q15283	Ras GTPase-activating protein 2	DEG_APCC_KENBOX_2	840:844	SKENP	APC,CDC20,FZR1	0.9812	More...
Q8TBG4	Ethanolamine-phosphate phospho-lyase	DEG_APCC_KENBOX_2	474:478	SKENP	APC,CDC20,FZR1	0.828	More...
Q8N999	Uncharacterized protein C12orf29	DEG_APCC_KENBOX_2	96:100	SKENP	APC,CDC20,FZR1	0.6542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons