DegronMD - Q8N999(C12orf29)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K97N	TCGA-E6-A1LX	UCEC	TCGA	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation altering degron motif	0.6918
p.K97N	DO41020	UCEC	ICGC	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation altering degron motif	0.6918
p.F93V	TCGA-EO-A22X	UCEC	TCGA	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation rewiring degron network	0.25
p.F93V	DO43907	UCEC	ICGC	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation rewiring degron network	0.25
p.W105R	TCGA-IB-7651	PAAD	TCGA	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation rewiring degron network	0.1944
p.W105R	DO46657	PAAD	ICGC	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation rewiring degron network	0.1944
p.R89K	DO233190	GACA	ICGC	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation rewiring degron network	0.1389
p.V107I	DO12382	GBM	ICGC	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation rewiring degron network	0.1389
p.W105G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SKENP	DEG_APCC_KENBOX_2	96:100	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons