DegronMD

Uniprot ID: Q15283

Source protein: Ras GTPase-activating protein 2

Source gene: RASA2

Class: DEG_APCC_KENBOX_2

Location: 840:844

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9812

ASA_SCORE: 65.1

COIL: 0.7094

CONS_SCORE: 0.3811

DSS_SCORE: 0.6636

HELIX: 0.1584

FCONS_SCORE: 1.0548

RIG_SCORE: 0.6429

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P843L	TCGA-18-3409	LUSC	TCGA	SKENP	DEG_APCC_KENBOX_2	0.7582
p.P843L	SIDM01175	Other Sarcomas	GDSC	SKENP	DEG_APCC_KENBOX_2	0.7582
p.P843L	ACH-002309	Sarcoma	CCLE	SKENP	DEG_APCC_KENBOX_2	0.7582
p.P843L	SW684	soft_tissue	COSMIC	SKENP	DEG_APCC_KENBOX_2	0.7582
p.P843S	TCGA-YD-A9TA	SKCM	TCGA	SKENP	DEG_APCC_KENBOX_2	0.6752
p.K837R	DO233081	GACA	ICGC	SKENP	DEG_APCC_KENBOX_2	0.3611
p.P844L	DO26444	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	0.6471
p.P844S	DO219503	SKCM	ICGC	SKENP	DEG_APCC_KENBOX_2	0.5641
p.P847L	SW684	soft_tissue	COSMIC	SKENP	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37802	Transgelin-2	DEG_APCC_KENBOX_2	155:159	SKENP	APC,CDC20,FZR1	0.9256	More...
Q15283	Ras GTPase-activating protein 2	DEG_APCC_KENBOX_2	840:844	SKENP	APC,CDC20,FZR1	0.9812	More...
Q8TBG4	Ethanolamine-phosphate phospho-lyase	DEG_APCC_KENBOX_2	474:478	SKENP	APC,CDC20,FZR1	0.828	More...
Q8N999	Uncharacterized protein C12orf29	DEG_APCC_KENBOX_2	96:100	SKENP	APC,CDC20,FZR1	0.6542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons