DegronMD

Uniprot ID: Q8TBG4

Source protein: Ethanolamine-phosphate phospho-lyase

Source gene: ETNPPL

Class: DEG_APCC_KENBOX_2

Location: 474:478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.828

ASA_SCORE: 96.22

COIL: 0.8522

CONS_SCORE: 0.1006

DSS_SCORE: 0.6747

HELIX: 0.1356

FCONS_SCORE: 1.1021

RIG_SCORE: 0.6285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D469E	TCGA-97-7937	LUAD	TCGA	SKENP	DEG_APCC_KENBOX_2	0.1944
p.D469E	DO25649	LUAD	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1944
p.I464V	TCGA-BR-4184	STAD	TCGA	SKENP	DEG_APCC_KENBOX_2	0.0556
p.I464V	DO38328	STAD	ICGC	SKENP	DEG_APCC_KENBOX_2	0.0556
p.G484A	TCGA-YC-A9TC	BLCA	TCGA	SKENP	DEG_APCC_KENBOX_2	0.1667
p.G484A	DO51949	BLCA	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1667
p.G484A	DO234278	ESAD	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1667
p.T487M	DO230342	COCA	ICGC	SKENP	DEG_APCC_KENBOX_2	0.0833
p.L466M	DO229006	LICA	ICGC	SKENP	DEG_APCC_KENBOX_2	0.1111
p.S474F	DO230940	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	0.6871
p.S474F	DO224584	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37802	Transgelin-2	DEG_APCC_KENBOX_2	155:159	SKENP	APC,CDC20,FZR1	0.9256	More...
Q15283	Ras GTPase-activating protein 2	DEG_APCC_KENBOX_2	840:844	SKENP	APC,CDC20,FZR1	0.9812	More...
Q8TBG4	Ethanolamine-phosphate phospho-lyase	DEG_APCC_KENBOX_2	474:478	SKENP	APC,CDC20,FZR1	0.828	More...
Q8N999	Uncharacterized protein C12orf29	DEG_APCC_KENBOX_2	96:100	SKENP	APC,CDC20,FZR1	0.6542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons