DegronMD - Q8TBG4(ETNPPL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E450Q	TCGA-69-7979	LUAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation altering degron motif	0.6744
p.E450Q	DO23874	LUAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation altering degron motif	0.6744
p.M458I	TCGA-75-6214	LUAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.25
p.M458I	DO24830	LUAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.25
p.D469E	TCGA-97-7937	LUAD	TCGA	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.1944
p.D469E	DO25649	LUAD	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.1944
p.A439D	TCGA-A5-A1OF	UCEC	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.0833
p.A439D	DO42568	UCEC	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.0833
p.I464V	TCGA-BR-4184	STAD	TCGA	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.0556
p.I464V	TCGA-BR-4184	STAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.0833
p.I464V	DO38328	STAD	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.0556
p.I464V	DO38328	STAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.0833
p.A439V	TCGA-DF-A2KU	UCEC	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.0833
p.A439V	DO223286	UCEC	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.0833
p.E445K	TCGA-KB-A6F7	STAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.25
p.E445K	DO48375	BLCA	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.25
p.E445K	DO50129	STAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.25
p.G484A	TCGA-YC-A9TC	BLCA	TCGA	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.1667
p.G484A	DO51949	BLCA	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.1667
p.G484A	DO234278	ESAD	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.1667
p.T487M	DO230342	COCA	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.0833
p.T456K	DO229045	LICA	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.3056
p.L466M	DO229006	LICA	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation rewiring degron network	0.1111
p.S474F	DO230940	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation altering degron motif	0.6871
p.S474F	DO224584	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	474:478	Mutation altering degron motif	0.6871
p.T452A	SIDM00537	Colorectal Carcinoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation altering degron motif	0.825
p.T452A	GP5d	large intestine	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation altering degron motif	0.825
p.E445D	SIDM00808	Burkitt's Lymphoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.25
p.E445D	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.25
p.P453L	SIDM01664	Prostate Carcinoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation altering degron motif	0.7582
p.K455N	SIDM01611	Endometrial Carcinoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation altering degron motif	0.6918
p.R456G	ACH-000771	Head and Neck Cancer	CCLE	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.3056
p.E439D	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.0833
p.T446A	GP5d	large intestine	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	448:455	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETNPPL

UniProt ID: Q8TBG4

Entrez ID: 64850

Protein name: Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETNPPL in