DegronMD

Uniprot ID: Q8TBG4

Source protein: Ethanolamine-phosphate phospho-lyase

Source gene: ETNPPL

Class: DEG_SCF_SKP2-CKS1_1

Location: 448:455

E3 ligase: SKP2,CSK1

DEGRON score: 0.91

ASA_SCORE: 88.9625

COIL: 0.8155

CONS_SCORE: 0.0932

DSS_SCORE: 0.5636

HELIX: 0.0906

FCONS_SCORE: 0.5704

RIG_SCORE: 0.7372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E450Q	TCGA-69-7979	LUAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.6744
p.E450Q	DO23874	LUAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.6744
p.M458I	TCGA-75-6214	LUAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.25
p.M458I	DO24830	LUAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.25
p.A439D	TCGA-A5-A1OF	UCEC	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A439D	DO42568	UCEC	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.0833
p.I464V	TCGA-BR-4184	STAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.0833
p.I464V	DO38328	STAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A439V	TCGA-DF-A2KU	UCEC	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A439V	DO223286	UCEC	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E445K	TCGA-KB-A6F7	STAD	TCGA	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.25
p.E445K	DO48375	BLCA	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.25
p.E445K	DO50129	STAD	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.25
p.T456K	DO229045	LICA	ICGC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.3056
p.T452A	SIDM00537	Colorectal Carcinoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.825
p.T452A	GP5d	large_intestine	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.825
p.E445D	SIDM00808	Burkitt's Lymphoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.25
p.E445D	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.25
p.P453L	SIDM01664	Prostate Carcinoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.7582
p.K455N	SIDM01611	Endometrial Carcinoma	GDSC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.6918
p.R456G	ACH-000771	Head and Neck Cancer	CCLE	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E439D	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.0833
p.T446A	GP5d	large_intestine	COSMIC	TSENTPCK	DEG_SCF_SKP2-CKS1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBG4	Ethanolamine-phosphate phospho-lyase	DEG_SCF_SKP2-CKS1_1	448:455	TSENTPCK	SKP2,CSK1	0.91	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSENTPCK

Degron related mutations and impact score

Drug responses associated with ETNPPL mutations

All proteins holding degron of TSENTPCK