DegronMD - Q15283(RASA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P843L	TCGA-18-3409	LUSC	TCGA	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation altering degron motif	0.7582
p.P843L	SIDM01175	Other Sarcomas	GDSC	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation altering degron motif	0.7582
p.P843L	ACH-002309	Sarcoma	CCLE	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation altering degron motif	0.7582
p.P843L	SW684	soft tissue	COSMIC	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation altering degron motif	0.7582
p.P843S	TCGA-YD-A9TA	SKCM	TCGA	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation altering degron motif	0.6752
p.K837R	DO233081	GACA	ICGC	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation substituting flanking lysine	0.3611
p.P844L	DO26444	LUSC	ICGC	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation altering degron motif	0.6471
p.P844S	DO219503	SKCM	ICGC	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation altering degron motif	0.5641
p.P847L	SW684	soft tissue	COSMIC	SKENP	DEG_APCC_KENBOX_2	840:844	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons