DegronMD - P38936(CDKN1A)

GO - Biological processes (BP): cellular response to amino acid starvation [GO:0034198]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to extracellular stimulus [GO:0031668]; cellular response to gamma radiation [GO:0071480]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV-B [GO:0071493]; cellular senescence [GO:0090398]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cardiac muscle tissue regeneration [GO:1905179]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein kinase activity [GO:1904030]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein binding [GO:0032091]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein import into nucleus [GO:0006606]; Ras protein signal transduction [GO:0007265]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; replicative senescence [GO:0090399]; stress-induced premature senescence [GO:0090400]; tissue regeneration [GO:0042246]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R162S	TCGA-05-4427	LUAD	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.1944
p.R162S	TCGA-05-4427	LUAD	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.1944
p.R162S	DO23666	LUAD	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.1944
p.R162S	DO23666	LUAD	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.1944
p.R140Q	TCGA-13-1403	OV	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2222
p.R140Q	TCGA-13-1403	OV	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2222
p.R140Q	DO28038	OV	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2222
p.R140Q	DO28038	OV	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2222
p.R142W	TCGA-AJ-A3BH	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142W	TCGA-AJ-A3BH	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.R142W	TCGA-AX-A2HC	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142W	TCGA-AX-A2HC	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.R142W	DO41638	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142W	DO41638	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.R142W	DO41572	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142W	DO41572	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.R142W	SIDM00615	Hepatocellular Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142W	SIDM00615	Hepatocellular Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.R142W	ACH-000217	Liver Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142W	ACH-000217	Liver Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.R142W	JHH-6	liver	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142W	JHH-6	liver	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.S153C	TCGA-C5-A8YR	CESC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.7541
p.S153C	TCGA-C5-A8YR	CESC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.7541
p.S153C	DO49908	CESC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.7541
p.S153C	DO49908	CESC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.7541
p.D136H	TCGA-CF-A1HS	BLCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.1111
p.D136H	TCGA-CF-A1HS	BLCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.1111
p.D136H	DO486	BLCA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.1111
p.D136H	DO486	BLCA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.1111
p.D149H	TCGA-DD-A4NE	LIHC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.7688
p.D149H	TCGA-DD-A4NE	LIHC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.7688
p.D149H	DO44889	LIHC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.7688
p.D149H	DO44889	LIHC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.7688
p.R155H	TCGA-FG-A6IZ	LGG	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.8244
p.R155H	TCGA-FG-A6IZ	LGG	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.8244
p.R155H	DO44584	LGG	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.8244
p.R155H	DO44584	LGG	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.8244
p.R155H	SIDM01966	Colorectal Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.8244
p.R155H	SIDM01966	Colorectal Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.8244
p.R155H	SIDM01608	Endometrial Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.8244
p.R155H	SIDM01608	Endometrial Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.8244
p.R155H	ACH-000990	Endometrial/Uterine Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.8244
p.R155H	ACH-000990	Endometrial/Uterine Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.8244
p.G135A	TCGA-IG-A3Y9	ESCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.0833
p.G135A	TCGA-IG-A3Y9	ESCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.0833
p.R143L	DO229018	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143L	DO229018	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.K163N	DO229006	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation blocking ubiquitination signal	0.6111
p.K163N	DO229006	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation blocking ubiquitination signal	0.6111
p.R142Q	DO220852	MELA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.2778
p.R142Q	DO220852	MELA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.2778
p.R156W	SIDM00131	Glioma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.7523
p.R156W	SIDM00131	Glioma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.7523
p.R156W	ACH-000329	Brain Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.7523
p.R156W	ACH-000329	Brain Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.7523
p.R156W	CCF-STTG1	central nervous system	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation altering degron motif	0.7523
p.R156W	CCF-STTG1	central nervous system	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation altering degron motif	0.7523
p.R143Q	SIDM00299	Other Sarcomas	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143Q	SIDM00299	Other Sarcomas	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143Q	SIDM01378	Ovarian Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143Q	SIDM01378	Ovarian Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143Q	SIDM01473	Plasma Cell Myeloma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143Q	SIDM01473	Plasma Cell Myeloma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143Q	ACH-000541	Myeloma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143Q	ACH-000541	Myeloma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143Q	ACH-000646	Ovarian Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143Q	ACH-000646	Ovarian Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143Q	ACH-002271	Sarcoma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143Q	ACH-002271	Sarcoma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143Q	MFH-ino	soft tissue	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143Q	MFH-ino	soft tissue	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143W	SIDM00999	Bladder Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143W	SIDM00999	Bladder Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143W	ACH-000973	Bladder Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143W	ACH-000973	Bladder Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056
p.R143W	639-V	urinary tract	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	144:157	Mutation rewiring degron network	0.3056
p.R143W	639-V	urinary tract	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	144:157	Mutation rewiring degron network	0.3056

Kaplan plot for CDKN1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDKN1A

UniProt ID: P38936

Entrez ID: 1026

Protein name: Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDKN1A in