DegronMD

Uniprot ID: P38936

Source protein: Cyclin-dependent kinase inhibitor 1

Source gene: CDKN1A

Class: DEG_CRL4_CDT2_1

Location: 144:157

E3 ligase: DTL

DEGRON score: 0.9982

ASA_SCORE: 97.1643

COIL: 0.7401

CONS_SCORE: 0.7101

DSS_SCORE: 0.7059

HELIX: 0.1517

FCONS_SCORE: 1.2646

RIG_SCORE: 0.7494

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R162S	TCGA-05-4427	LUAD	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.1944
p.R162S	TCGA-05-4427	LUAD	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.1944
p.R162S	DO23666	LUAD	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.1944
p.R162S	DO23666	LUAD	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.1944
p.R140Q	TCGA-13-1403	OV	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2222
p.R140Q	TCGA-13-1403	OV	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2222
p.R140Q	DO28038	OV	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2222
p.R140Q	DO28038	OV	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2222
p.R142W	TCGA-AJ-A3BH	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142W	TCGA-AJ-A3BH	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.R142W	TCGA-AX-A2HC	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142W	TCGA-AX-A2HC	UCEC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.R142W	DO41638	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142W	DO41638	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.R142W	DO41572	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142W	DO41572	UCEC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.R142W	SIDM00615	Hepatocellular Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142W	SIDM00615	Hepatocellular Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.R142W	ACH-000217	Liver Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142W	ACH-000217	Liver Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.R142W	JHH-6	liver	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142W	JHH-6	liver	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.S153C	TCGA-C5-A8YR	CESC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.7541
p.S153C	TCGA-C5-A8YR	CESC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.7541
p.S153C	DO49908	CESC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.7541
p.S153C	DO49908	CESC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.7541
p.D136H	TCGA-CF-A1HS	BLCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.1111
p.D136H	TCGA-CF-A1HS	BLCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.1111
p.D136H	DO486	BLCA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.1111
p.D136H	DO486	BLCA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.1111
p.D149H	TCGA-DD-A4NE	LIHC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.7688
p.D149H	TCGA-DD-A4NE	LIHC	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.7688
p.D149H	DO44889	LIHC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.7688
p.D149H	DO44889	LIHC	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.7688
p.R155H	TCGA-FG-A6IZ	LGG	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.8244
p.R155H	TCGA-FG-A6IZ	LGG	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.8244
p.R155H	DO44584	LGG	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.8244
p.R155H	DO44584	LGG	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.8244
p.R155H	SIDM01966	Colorectal Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.8244
p.R155H	SIDM01966	Colorectal Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.8244
p.R155H	SIDM01608	Endometrial Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.8244
p.R155H	SIDM01608	Endometrial Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.8244
p.R155H	ACH-000990	Endometrial/Uterine Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.8244
p.R155H	ACH-000990	Endometrial/Uterine Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.8244
p.G135A	TCGA-IG-A3Y9	ESCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.0833
p.G135A	TCGA-IG-A3Y9	ESCA	TCGA	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.0833
p.R143L	DO229018	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143L	DO229018	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.K163N	DO229006	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.6111
p.K163N	DO229006	LICA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.6111
p.R142Q	DO220852	MELA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.2778
p.R142Q	DO220852	MELA	ICGC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.2778
p.R156W	SIDM00131	Glioma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.7523
p.R156W	SIDM00131	Glioma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.7523
p.R156W	ACH-000329	Brain Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.7523
p.R156W	ACH-000329	Brain Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.7523
p.R156W	CCF-STTG1	central_nervous_system	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.7523
p.R156W	CCF-STTG1	central_nervous_system	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.7523
p.R143Q	SIDM00299	Other Sarcomas	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143Q	SIDM00299	Other Sarcomas	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143Q	SIDM01378	Ovarian Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143Q	SIDM01378	Ovarian Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143Q	SIDM01473	Plasma Cell Myeloma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143Q	SIDM01473	Plasma Cell Myeloma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143Q	ACH-000541	Myeloma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143Q	ACH-000541	Myeloma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143Q	ACH-000646	Ovarian Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143Q	ACH-000646	Ovarian Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143Q	ACH-002271	Sarcoma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143Q	ACH-002271	Sarcoma	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143Q	MFH-ino	soft_tissue	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143Q	MFH-ino	soft_tissue	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143W	SIDM00999	Bladder Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143W	SIDM00999	Bladder Carcinoma	GDSC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143W	ACH-000973	Bladder Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143W	ACH-000973	Bladder Cancer	CCLE	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056
p.R143W	639-V	urinary_tract	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_1	0.3056
p.R143W	639-V	urinary_tract	COSMIC	QTSMTDFYHSKRRL	DEG_CRL4_CDT2_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QTSMTDFYHSKRRL

Degron related mutations and impact score

Drug responses associated with CDKN1A mutations

All proteins holding degron of QTSMTDFYHSKRRL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38936	Cyclin-dependent kinase inhibitor 1	DEG_CRL4_CDT2_1	144:157	QTSMTDFYHSKRRL	DTL	0.9982	More...
P38936	Cyclin-dependent kinase inhibitor 1	DEG_CRL4_CDT2_1	144:157	QTSMTDFYHSKRRL	DTL	0.9982	More...
P38936	Cyclin-dependent kinase inhibitor 1	DEG_CRL4_CDT2_2	144:157	QTSMTDFYHSKRRL	DTL	0.9982	More...