DegronMD - P40199(CEACAM6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T135N	TCGA-39-5016	LUSC	TCGA	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.T135N	DO26701	LUSC	ICGC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.G136V	TCGA-AP-A056	UCEC	TCGA	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778
p.G136V	DO43971	UCEC	ICGC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778
p.P142S	TCGA-B6-A0IQ	BRCA	TCGA	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	DO4847	BRCA	ICGC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	DO38727	STAD	ICGC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	PF-382	haematopoietic and lymphoid tissue	COSMIC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.L129I	TCGA-EO-A22X	UCEC	TCGA	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.L129I	DO43907	UCEC	ICGC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0833
p.Q137R	TCGA-IB-7651	PAAD	TCGA	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137R	DO46657	PAAD	ICGC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.I149M	DO49797	BLCA	ICGC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1667
p.E133G	SIDM00773	Non-Cancerous	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM01126	Small Cell Lung Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00656	Burkitt's Lymphoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00087	Plasma Cell Myeloma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00447	B-Lymphoblastic Leukemia	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00761	Small Cell Lung Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00971	Breast Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00479	Esophageal Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00808	Burkitt's Lymphoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM01173	Rhabdomyosarcoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM00641	Burkitt's Lymphoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.E133G	SIDM01254	Burkitt's Lymphoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1944
p.D128N	SIDM00614	Hepatocellular Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.D128N	ACH-000848	Liver Cancer	CCLE	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.D128N	JHH-7	liver	COSMIC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.Y141H	SIDM00383	Gastric Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6118
p.Y141H	SCH	stomach	COSMIC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6118
p.S150F	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1389
p.S150F	ACH-000875	Lung Cancer	CCLE	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1389
p.S150F	NCI-H2347	lung	COSMIC	FHVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.1389

Kaplan plot for CEACAM6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEACAM6

UniProt ID: P40199

Entrez ID: 4680

Protein name: Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEACAM6 in