DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
FHVYPE
Uniprot ID:
P40199
Source protein:
Carcinoembryonic antigen-related cell adhesion molecule 6
Source gene:
CEACAM6
Class:
LIG_APCC_ABBA_1
Location:
138:143
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7583
ASA_SCORE:
53.8167
COIL:
0.476
CONS_SCORE:
0.4236
DSS_SCORE:
0.4598
HELIX:
0.0285
FCONS_SCORE:
1.0215
RIG_SCORE:
0.8083
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T135N
TCGA-39-5016
LUSC
TCGA
FHVYPE
LIG_APCC_ABBA_1
0.25
p.T135N
DO26701
LUSC
ICGC
FHVYPE
LIG_APCC_ABBA_1
0.25
p.G136V
TCGA-AP-A056
UCEC
TCGA
FHVYPE
LIG_APCC_ABBA_1
0.2778
p.G136V
DO43971
UCEC
ICGC
FHVYPE
LIG_APCC_ABBA_1
0.2778
p.P142S
TCGA-B6-A0IQ
BRCA
TCGA
FHVYPE
LIG_APCC_ABBA_1
0.5641
p.P142S
DO4847
BRCA
ICGC
FHVYPE
LIG_APCC_ABBA_1
0.5641
p.P142S
DO38727
STAD
ICGC
FHVYPE
LIG_APCC_ABBA_1
0.5641
p.P142S
SIDM00451
T-Lymphoblastic Leukemia
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.5641
p.P142S
PF-382
haematopoietic_and_lymphoid_tissue
COSMIC
FHVYPE
LIG_APCC_ABBA_1
0.5641
p.L129I
TCGA-EO-A22X
UCEC
TCGA
FHVYPE
LIG_APCC_ABBA_1
0.0833
p.L129I
DO43907
UCEC
ICGC
FHVYPE
LIG_APCC_ABBA_1
0.0833
p.Q137R
TCGA-IB-7651
PAAD
TCGA
FHVYPE
LIG_APCC_ABBA_1
0.3056
p.Q137R
DO46657
PAAD
ICGC
FHVYPE
LIG_APCC_ABBA_1
0.3056
p.I149M
DO49797
BLCA
ICGC
FHVYPE
LIG_APCC_ABBA_1
0.1667
p.E133G
SIDM00773
Non-Cancerous
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM01126
Small Cell Lung Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00656
Burkitt's Lymphoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00087
Plasma Cell Myeloma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00447
B-Lymphoblastic Leukemia
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00761
Small Cell Lung Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00052
Esophageal Squamous Cell Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00971
Breast Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00479
Esophageal Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00808
Burkitt's Lymphoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM01173
Rhabdomyosarcoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM00641
Burkitt's Lymphoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.E133G
SIDM01254
Burkitt's Lymphoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1944
p.D128N
SIDM00614
Hepatocellular Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.0556
p.D128N
ACH-000848
Liver Cancer
CCLE
FHVYPE
LIG_APCC_ABBA_1
0.0556
p.D128N
JHH-7
liver
COSMIC
FHVYPE
LIG_APCC_ABBA_1
0.0556
p.Y141H
SIDM00383
Gastric Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.6118
p.Y141H
SCH
stomach
COSMIC
FHVYPE
LIG_APCC_ABBA_1
0.6118
p.S150F
SIDM00726
Non-Small Cell Lung Carcinoma
GDSC
FHVYPE
LIG_APCC_ABBA_1
0.1389
p.S150F
ACH-000875
Lung Cancer
CCLE
FHVYPE
LIG_APCC_ABBA_1
0.1389
p.S150F
NCI-H2347
lung
COSMIC
FHVYPE
LIG_APCC_ABBA_1
0.1389
Drug responses associated with CEACAM6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FHVYPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13688
Carcinoembryonic antigen-related cell adhesion molecule 1
LIG_APCC_ABBA_1
138:143
FHVYPE
APC,CDC20,FZR1
0.8334
More...
P40199
Carcinoembryonic antigen-related cell adhesion molecule 6
LIG_APCC_ABBA_1
138:143
FHVYPE
APC,CDC20,FZR1
0.7583
More...