DegronMD

Uniprot ID: P13688

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 1

Source gene: CEACAM1

Class: LIG_APCC_ABBA_1

Location: 138:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8334

ASA_SCORE: 60.7

COIL: 0.5822

CONS_SCORE: 0.6068

DSS_SCORE: 0.466

HELIX: 0.0333

FCONS_SCORE: 0.9461

RIG_SCORE: 0.8083

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.PE142PK	DO222521	MELA	ICGC	FHVYPE	LIG_APCC_ABBA_1	0.7312
p.E143G	SIDM00498	Colorectal Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	0.7199
p.E143G	ACH-000970	Colon/Colorectal Cancer	CCLE	FHVYPE	LIG_APCC_ABBA_1	0.7199
p.E143G	SNU-C5	large_intestine	COSMIC	FHVYPE	LIG_APCC_ABBA_1	0.7199
p.P145L	DO220893	MELA	ICGC	FHVYPE	LIG_APCC_ABBA_1	0.2778
p.A134T	TCGA-VQ-A8PB	STAD	TCGA	FHVYPE	LIG_APCC_ABBA_1	0.2222
p.A134T	DO51766	STAD	ICGC	FHVYPE	LIG_APCC_ABBA_1	0.2222
p.E132A	SIDM00850	Gastric Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	0.1667
p.E132A	ACH-000880	Gastric Cancer	CCLE	FHVYPE	LIG_APCC_ABBA_1	0.1667
p.E132A	AGS	stomach	COSMIC	FHVYPE	LIG_APCC_ABBA_1	0.1667
p.S150P	SIDM01608	Endometrial Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	0.1389
p.S150P	ACH-000990	Endometrial/Uterine Cancer	CCLE	FHVYPE	LIG_APCC_ABBA_1	0.1389
p.S151I	TCGA-05-4250	LUAD	TCGA	FHVYPE	LIG_APCC_ABBA_1	0.1111
p.S151I	DO24457	LUAD	ICGC	FHVYPE	LIG_APCC_ABBA_1	0.1111
p.S151T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	FHVYPE	LIG_APCC_ABBA_1	0.1111
p.S151T	ACH-000062	Lung Cancer	CCLE	FHVYPE	LIG_APCC_ABBA_1	0.1111
p.S151T	RERF-LC-MS	lung	COSMIC	FHVYPE	LIG_APCC_ABBA_1	0.1111
p.L129F	TCGA-AX-A05Z	UCEC	TCGA	FHVYPE	LIG_APCC_ABBA_1	0.0833
p.L129F	DO40884	UCEC	ICGC	FHVYPE	LIG_APCC_ABBA_1	0.0833
p.L129I	DO222884	COCA	ICGC	FHVYPE	LIG_APCC_ABBA_1	0.0833
p.E128K	DO37819	SKCM	ICGC	FHVYPE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 21 of 21 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13688	Carcinoembryonic antigen-related cell adhesion molecule 1	LIG_APCC_ABBA_1	138:143	FHVYPE	APC,CDC20,FZR1	0.8334	More...
P40199	Carcinoembryonic antigen-related cell adhesion molecule 6	LIG_APCC_ABBA_1	138:143	FHVYPE	APC,CDC20,FZR1	0.7583	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons