DegronMD - P40222(TXLNA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R250W	TCGA-A6-3809	COAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1944
p.R250W	DO8722	COAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1944
p.G229S	TCGA-BF-A1PV	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.G229S	DO47309	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.G229S	SIDM00457	Plasma Cell Myeloma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.G229S	ACH-000024	Myeloma	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.G229S	ACH-000057	Myeloma	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.G229S	ACH-001354	Neuroblastoma	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.G229S	OPM-2	haematopoietic and lymphoid tissue	COSMIC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.R246H	TCGA-D3-A8GM	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.R246H	DO50288	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.C245Y	TCGA-EY-A2OP	UCEC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.5976
p.C245Y	DO42560	UCEC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.5976
p.R246S	TCGA-GN-A262	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.R246S	DO37515	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.E247D	TCGA-X6-A7WB	SARC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.E247D	DO220314	SARC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.R228H	TCGA-XK-AAIW	PRAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0833
p.R228H	DO51407	PRAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0833
p.R253H	DO232224	PBCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.R253H	SIDM01307	Colorectal Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.R253H	ACH-001610	Brain Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1111
p.V235I	DO229211	THCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.V235I	SIDM01617	Endometrial Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.V235A	ACH-000997	Colon/Colorectal Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.V235A	ACH-001061	Colon/Colorectal Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.V235A	HCT-15	large intestine	COSMIC	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.N252H	ACH-001977	Primary	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1389

Kaplan plot for TXLNA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TXLNA

UniProt ID: P40222

Entrez ID: 200081

Protein name: Alpha-taxilin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TXLNA in