DegronMD

Uniprot ID: P40222

Source protein: Alpha-taxilin

Source gene: TXLNA

Class: DEG_APCC_DBOX_1

Location: 237:245

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9757

ASA_SCORE: 74.0333

COIL: 0.0744

CONS_SCORE: 0.6673

DSS_SCORE: 0.3892

HELIX: 0.9247

FCONS_SCORE: 1.3171

RIG_SCORE: 0.7447

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R250W	TCGA-A6-3809	COAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.1944
p.R250W	DO8722	COAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.1944
p.G229S	TCGA-BF-A1PV	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.G229S	DO47309	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.G229S	SIDM00457	Plasma Cell Myeloma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.G229S	ACH-000024	Myeloma	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.G229S	ACH-000057	Myeloma	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.G229S	ACH-001354	Neuroblastoma	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.G229S	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.R246H	TCGA-D3-A8GM	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.3056
p.R246H	DO50288	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.3056
p.C245Y	TCGA-EY-A2OP	UCEC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.5976
p.C245Y	DO42560	UCEC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.5976
p.R246S	TCGA-GN-A262	SKCM	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.3056
p.R246S	DO37515	SKCM	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.3056
p.E247D	TCGA-X6-A7WB	SARC	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.E247D	DO220314	SARC	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.R228H	TCGA-XK-AAIW	PRAD	TCGA	ARSKLESLC	DEG_APCC_DBOX_1	0.0833
p.R228H	DO51407	PRAD	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.0833
p.R253H	DO232224	PBCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.R253H	SIDM01307	Colorectal Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.R253H	ACH-001610	Brain Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.1111
p.V235I	DO229211	THCA	ICGC	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.V235I	SIDM01617	Endometrial Carcinoma	GDSC	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.V235A	ACH-000997	Colon/Colorectal Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.V235A	ACH-001061	Colon/Colorectal Cancer	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.V235A	HCT-15	large_intestine	COSMIC	ARSKLESLC	DEG_APCC_DBOX_1	0.2778
p.N252H	ACH-001977	Primary	CCLE	ARSKLESLC	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40222	Alpha-taxilin	DEG_APCC_DBOX_1	237:245	ARSKLESLC	APC,CDC20,FZR1	0.9757	More...
Q8N3L3	Beta-taxilin	DEG_APCC_DBOX_1	210:218	ARSKLESLC	APC,CDC20,FZR1	0.6533	More...
Q9NUQ3	Gamma-taxilin	DEG_APCC_DBOX_1	204:212	ARSKLESLC	APC,CDC20,FZR1	0.5353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSKLESLC

Degron related mutations and impact score

Drug responses associated with TXLNA mutations

All proteins holding degron of ARSKLESLC